Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2328393..2329011 Replicon chromosome
Accession NZ_CP071697
Organism Streptococcus suis strain 1112S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J1N58_RS11040 Protein ID WP_099778123.1
Coordinates 2328670..2329011 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J1N58_RS11035 Protein ID WP_099778124.1
Coordinates 2328393..2328680 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1N58_RS11010 2324687..2325610 - 924 WP_044672943.1 zinc ABC transporter substrate-binding protein -
J1N58_RS11015 2325736..2326395 + 660 WP_024414549.1 metal-dependent transcriptional regulator -
J1N58_RS11020 2326409..2326684 - 276 WP_024377609.1 hypothetical protein -
J1N58_RS11025 2326780..2327454 - 675 WP_024377608.1 CPBP family intramembrane metalloprotease -
J1N58_RS11030 2327517..2327993 - 477 WP_207560368.1 CPBP family intramembrane metalloprotease -
J1N58_RS11035 2328393..2328680 + 288 WP_099778124.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J1N58_RS11040 2328670..2329011 + 342 WP_099778123.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1N58_RS11045 2329106..2329300 - 195 WP_099778122.1 hypothetical protein -
J1N58_RS11050 2329322..2330023 - 702 WP_100881806.1 CPBP family intramembrane metalloprotease -
J1N58_RS11055 2330027..2330437 - 411 WP_100881807.1 hypothetical protein -
J1N58_RS11060 2330472..2330654 - 183 WP_024377601.1 hypothetical protein -
J1N58_RS11065 2330877..2331038 - 162 WP_153603303.1 hypothetical protein -
J1N58_RS11070 2332205..2332366 - 162 WP_153597537.1 hypothetical protein -
J1N58_RS11075 2332675..2332842 - 168 WP_158293418.1 hypothetical protein -
J1N58_RS11080 2332916..2333077 - 162 WP_153308666.1 hypothetical protein -
J1N58_RS11085 2333118..2333276 - 159 WP_002942002.1 hypothetical protein -
J1N58_RS11090 2333383..2333592 - 210 WP_044678691.1 hypothetical protein -
J1N58_RS11095 2333610..2333771 - 162 WP_153309488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13094.13 Da        Isoelectric Point: 8.3772

>T196739 WP_099778123.1 NZ_CP071697:2328670-2329011 [Streptococcus suis]
MVYEVHLSAKAEKDLEEIYQYYVREFSESSARKVLASLSTAILTLEIFPEGYIDLDARLGRALFPEGKTRMIPGKQHLIF
YLIRGSHVDILRIRGARTDYLNNLDNLFKQTLK

Download         Length: 342 bp

>T196739 NZ_CP095276:c3959929-3959519 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10873.36 Da        Isoelectric Point: 4.1956

>AT196739 WP_099778124.1 NZ_CP071697:2328393-2328680 [Streptococcus suis]
MAGLVRDRQYNFRVNAQLLEQAKIILSEKDMTLSDALNLFVERMVEEQDLPIKTVEEVRAEAFLDELIAELDEGYQEVLS
GHTTPAREVFAKYGL

Download         Length: 288 bp

>AT196739 NZ_CP095276:c3960176-3959910 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References