Detailed information of TA system TA196738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2232125..2232731
• Replicon: chromosome
• Accession: NZ_CP071697
• Organism: Streptococcus suis strain 1112S

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J1N58_RS10605
• Protein ID: WP_024376095.1
• Coordinates: 2232125..2232454 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0Z8H9V4
• Locus tag: J1N58_RS10610
• Protein ID: WP_024376096.1
• Coordinates: 2232444..2232731 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1N58_RS10575	2227700..2229430	-	1731	WP_207560352.1	hypothetical protein	-
J1N58_RS10580	2229632..2230540	-	909	WP_079267516.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
J1N58_RS10585	2230524..2231054	-	531	WP_029176516.1	DUF1697 domain-containing protein	-
J1N58_RS10590	2231068..2231325	-	258	WP_029176515.1	Txe/YoeB family addiction module toxin	-
J1N58_RS10595	2231327..2231587	-	261	WP_029693536.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J1N58_RS10600	2231663..2232118	-	456	WP_207560353.1	NUDIX domain-containing protein	-
J1N58_RS10605	2232125..2232454	-	330	WP_024376095.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J1N58_RS10610	2232444..2232731	-	288	WP_024376096.1	hypothetical protein	Antitoxin
J1N58_RS10615	2232829..2233197	-	369	WP_207560354.1	hypothetical protein	-
J1N58_RS10620	2233190..2233759	-	570	WP_207560355.1	ribonuclease M5	-
J1N58_RS10625	2233743..2234525	-	783	WP_207560356.1	YchF/TatD family DNA exonuclease	-
J1N58_RS10630	2234610..2234747	-	138	WP_002939016.1	50S ribosomal protein L34	-
J1N58_RS10635	2234915..2235910	-	996	WP_002940330.1	protein jag	-
J1N58_RS10640	2235930..2236742	-	813	WP_024377969.1	YidC/Oxa1 family membrane protein insertase	-
J1N58_RS10645	2236726..2237085	-	360	WP_024377970.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12649.65 Da
• Isoelectric Point: 5.9062

>T196738 WP_024376095.1 NZ_CP071697:c2232454-2232125 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPYLTRGYVIGKD
YIALYRVVEKEMRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T196738 NZ_CP095276:3732145-3732444 [Enterobacter hormaechei subsp. xiangfangensis]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10943.55 Da
• Isoelectric Point: 4.5915

>AT196738 WP_024376096.1 NZ_CP071697:c2232731-2232444 [Streptococcus suis]
MITIKKDAQVNFKTDSRLLEKAKEVFAVNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLERVKEKYGI

Nucleotide

• Length: 288 bp

>AT196738 NZ_CP095276:3732455-3732820 [Enterobacter hormaechei subsp. xiangfangensis]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8H9V4