Detailed information of TA system TA196736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 1193384..1194645
• Replicon: chromosome
• Accession: NZ_CP071697
• Organism: Streptococcus suis strain 1112S

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: J1N58_RS05725
• Protein ID: WP_207560603.1
• Coordinates: 1193384..1194169 (-)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A0Z8GUV4
• Locus tag: J1N58_RS05730
• Protein ID: WP_024418311.1
• Coordinates: 1194169..1194645 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / optrA / erm(B)	-	1083566..1251754	168188

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (30-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 29951.03 Da
• Isoelectric Point: 5.9830

>T196736 WP_207560603.1 NZ_CP071697:c1194169-1193384 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPVQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPCQTAQLLRSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYTIDPNQARATPKEHHDGIIENLVDNLRELEREQLFDCIQIYQRDRTCIYDSKTDKDSAAEVLQNCLFGEWSKVEEEMM
KLGRERLQELIEDNILQNNIK

Nucleotide

• Length: 786 bp

>T196736 NZ_CP095276:c2842429-2842326 [Enterobacter hormaechei subsp. xiangfangensis]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18342.82 Da
• Isoelectric Point: 4.4829

>AT196736 WP_024418311.1 NZ_CP071697:c1194645-1194169 [Streptococcus suis]
MIGDNIKSLRRTHELTQPEFAKMIGISRNSLSRYENGTSKVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT196736 NZ_CP095276:2842313-2842522 [Enterobacter hormaechei subsp. xiangfangensis]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Antitoxin

• AlphaFold DB: A0A0Z8GUV4