Detailed information of TA system TA196736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 1193384..1194645
• Replicon: chromosome
• Accession: NZ_CP071697
• Organism: Streptococcus suis strain 1112S

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: J1N58_RS05725
• Protein ID: WP_207560603.1
• Coordinates: 1193384..1194169 (-)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A0Z8GUV4
• Locus tag: J1N58_RS05730
• Protein ID: WP_024418311.1
• Coordinates: 1194169..1194645 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1N58_RS05700	1189040..1189405	-	366	WP_024380649.1	MobC family plasmid mobilization relaxosome protein	-
J1N58_RS05705	1189415..1189774	-	360	WP_207560602.1	hypothetical protein	-
J1N58_RS05710	1190146..1190766	-	621	WP_024418307.1	TIR domain-containing protein	-
J1N58_RS05715	1190766..1192175	-	1410	WP_024418308.1	SIR2 family protein	-
J1N58_RS05720	1192205..1193365	-	1161	WP_024418309.1	toll/interleukin-1 receptor domain-containing protein	-
J1N58_RS05725	1193384..1194169	-	786	WP_207560603.1	zeta toxin family protein	Toxin
J1N58_RS05730	1194169..1194645	-	477	WP_024418311.1	helix-turn-helix domain-containing protein	Antitoxin
J1N58_RS05735	1194715..1195005	-	291	WP_029180369.1	hypothetical protein	-
J1N58_RS05740	1195055..1195444	-	390	WP_002935071.1	hypothetical protein	-
J1N58_RS05745	1195441..1195668	-	228	WP_002935073.1	hypothetical protein	-
J1N58_RS05750	1195722..1196798	-	1077	WP_024378757.1	toprim domain-containing protein	-
J1N58_RS05755	1196838..1197476	-	639	WP_024378756.1	hypothetical protein	-
J1N58_RS05760	1197609..1197877	+	269	Protein_1089	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / optrA / erm(B)	-	1083566..1251754	168188

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (30-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 29951.03 Da
• Isoelectric Point: 5.9830

>T196736 WP_207560603.1 NZ_CP071697:c1194169-1193384 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPVQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPCQTAQLLRSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYTIDPNQARATPKEHHDGIIENLVDNLRELEREQLFDCIQIYQRDRTCIYDSKTDKDSAAEVLQNCLFGEWSKVEEEMM
KLGRERLQELIEDNILQNNIK

Nucleotide

• Length: 786 bp

>T196736 NZ_CP095276:c2842429-2842326 [Enterobacter hormaechei subsp. xiangfangensis]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18342.82 Da
• Isoelectric Point: 4.4829

>AT196736 WP_024418311.1 NZ_CP071697:c1194645-1194169 [Streptococcus suis]
MIGDNIKSLRRTHELTQPEFAKMIGISRNSLSRYENGTSKVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT196736 NZ_CP095276:2842313-2842522 [Enterobacter hormaechei subsp. xiangfangensis]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Antitoxin

• AlphaFold DB: A0A0Z8GUV4