Detailed information of TA system TA196735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1168217..1168703
• Replicon: chromosome
• Accession: NZ_CP071697
• Organism: Streptococcus suis strain 1112S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J1N58_RS05585
• Protein ID: WP_105182497.1
• Coordinates: 1168217..1168474 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A123SEG2
• Locus tag: J1N58_RS05590
• Protein ID: WP_015646833.1
• Coordinates: 1168464..1168703 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1N58_RS05565	1163847..1164917	+	1071	WP_099809149.1	tyrosine recombinase XerS	-
J1N58_RS05570	1164987..1166495	-	1509	WP_207560600.1	phosphomannomutase/phosphoglucomutase	-
J1N58_RS05575	1166572..1167513	-	942	WP_105096430.1	sensor histidine kinase	-
J1N58_RS05580	1167510..1168178	-	669	WP_207560623.1	winged helix-turn-helix domain-containing protein	-
J1N58_RS05585	1168217..1168474	-	258	WP_105182497.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J1N58_RS05590	1168464..1168703	-	240	WP_015646833.1	hypothetical protein	Antitoxin
J1N58_RS05595	1168794..1170764	-	1971	WP_105182496.1	FtsX-like permease family protein	-
J1N58_RS05600	1170765..1171517	-	753	WP_024400583.1	ABC transporter ATP-binding protein	-
J1N58_RS05605	1171534..1171917	-	384	WP_024418298.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
J1N58_RS05610	1171930..1172070	-	141	WP_032499492.1	hypothetical protein	-
J1N58_RS05615	1172475..1173641	-	1167	WP_032510490.1	ATP-grasp domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / optrA / erm(B)	-	1083566..1251754	168188

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9816.56 Da
• Isoelectric Point: 10.8468

>T196735 WP_105182497.1 NZ_CP071697:c1168474-1168217 [Streptococcus suis]
MSYKVILSAKAQKQIRKLDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEIDKLILTSLKM
RNGSI

Nucleotide

• Length: 258 bp

>T196735 NZ_CP095276:c2378936-2378451 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCTTCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8879.09 Da
• Isoelectric Point: 3.7832

>AT196735 WP_015646833.1 NZ_CP071697:c1168703-1168464 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT196735 NZ_CP095276:c2379190-2378924 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A123SEG2