Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 917941..918545 Replicon chromosome
Accession NZ_CP071697
Organism Streptococcus suis strain 1112S

Toxin (Protein)


Gene name hicA Uniprot ID A0A0M9FK57
Locus tag J1N58_RS04475 Protein ID WP_024375895.1
Coordinates 918354..918545 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0M9FJP6
Locus tag J1N58_RS04470 Protein ID WP_024375896.1
Coordinates 917941..918318 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1N58_RS04445 913116..913472 + 357 WP_105141707.1 ArsC family transcriptional regulator -
J1N58_RS04450 913484..914293 + 810 WP_207560571.1 purine-nucleoside phosphorylase -
J1N58_RS04455 914319..914480 + 162 WP_002940467.1 hypothetical protein -
J1N58_RS04460 914502..915215 + 714 WP_024415758.1 purine-nucleoside phosphorylase -
J1N58_RS04465 915353..917620 + 2268 WP_207560572.1 glycogen/starch/alpha-glucan family phosphorylase -
J1N58_RS04470 917941..918318 - 378 WP_024375896.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1N58_RS04475 918354..918545 - 192 WP_024375895.1 type II toxin-antitoxin system HicA family toxin Toxin
J1N58_RS04480 918966..919625 + 660 WP_079267778.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7017.28 Da        Isoelectric Point: 10.6194

>T196734 WP_024375895.1 NZ_CP071697:c918545-918354 [Streptococcus suis]
MPLTGKEMAKLAEANGWKEIRVNGSHHHFKKEGFSKIVTIPVHGNKDLGKGLEKKILRDLGLL

Download         Length: 192 bp

>T196734 NZ_CP095276:1675705-1676226 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14195.03 Da        Isoelectric Point: 4.2530

>AT196734 WP_024375896.1 NZ_CP071697:c918318-917941 [Streptococcus suis]
MLKSYPAIFHKDEQGYWVEFPEFSGGTQGDNLEEAMYNARDFLESSIALYIDEGMELPKVSDIKELSAPDGFVSMIQADP
TPYIKNNKAIRKNVTVPEWLTKLADREGLNYSEILTTALETRLQV

Download         Length: 378 bp

>AT196734 NZ_CP095276:1675429-1675698 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FK57

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FJP6

References