Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2951956..2952605 Replicon chromosome
Accession NZ_CP071696
Organism Agromyces archimandritae strain G127AT

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G127AT_RS13550 Protein ID WP_210897730.1
Coordinates 2951956..2952375 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G127AT_RS13555 Protein ID WP_210902160.1
Coordinates 2952372..2952605 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G127AT_RS13525 (G127AT_13525) 2947697..2949403 - 1707 WP_210897722.1 glycosyl hydrolase family 18 protein -
G127AT_RS13530 (G127AT_13530) 2949539..2950689 + 1151 WP_210897724.1 IS3 family transposase -
G127AT_RS13540 (G127AT_13540) 2951335..2951616 - 282 WP_210897726.1 HAD-IA family hydrolase -
G127AT_RS13545 (G127AT_13545) 2951613..2951804 - 192 WP_210897728.1 hypothetical protein -
G127AT_RS13550 (G127AT_13550) 2951956..2952375 - 420 WP_210897730.1 type II toxin-antitoxin system VapC family toxin Toxin
G127AT_RS13555 (G127AT_13555) 2952372..2952605 - 234 WP_210902160.1 Arc family DNA-binding protein Antitoxin
G127AT_RS13560 (G127AT_13560) 2952890..2954686 - 1797 WP_210897732.1 hypothetical protein -
G127AT_RS13565 (G127AT_13565) 2954755..2956959 - 2205 WP_210897734.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin

Arc-like DNA binding domain

(11-39)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14934.02 Da        Isoelectric Point: 4.7381

>T196733 WP_210897730.1 NZ_CP071696:c2952375-2951956 [Agromyces archimandritae]
VIILDTNVISEGFRSRPEPSVIAWMETLVDEVSITAITLAELLAGVRRLPEGARKAALTAGIDTALDDYRQSAAILAFDD
RAAERYADILTIRERAGLPISSADAQIAAICRVHGATLATRNTKDFEKTGVALVNPWSA

Download         Length: 420 bp

>T196733 NZ_CP095276:c1182680-1182369 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCACATAGTCTCAAGAGCACCTTTCGACACAGCGGCCAGACATTATCCCAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAACACTACCCCTTACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTGAGCGGGGAAAGATC
TTCATCAAACACATCAGCACTCACGCAGACTATGACAAGCTCATGGACTACTACCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8347.37 Da        Isoelectric Point: 6.4818

>AT196733 WP_210902160.1 NZ_CP071696:c2952605-2952372 [Agromyces archimandritae]
MASVIVRGLDESVKSRIAEQAKEHGRSMEAEIRHILTRAAHRPHIGIALMRAAQAAGGADDLETPDRTDTARAADFE

Download         Length: 234 bp

>AT196733 NZ_CP095276:c1182372-1181953 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAACTCCCTTTCCTGGGTTCAAGCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGAGATGCTTACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAGTTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGTGATTTTGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAACGGACAGCGCACCTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTAGGGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References