Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2852186..2852841 Replicon chromosome
Accession NZ_CP071696
Organism Agromyces archimandritae strain G127AT

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G127AT_RS13110 Protein ID WP_210897579.1
Coordinates 2852416..2852841 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G127AT_RS13105 Protein ID WP_210897576.1
Coordinates 2852186..2852419 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G127AT_RS13085 (G127AT_13085) 2848505..2849759 + 1255 Protein_2593 ISL3 family transposase -
G127AT_RS13090 (G127AT_13090) 2849858..2850034 - 177 WP_210897573.1 hypothetical protein -
G127AT_RS13100 (G127AT_13100) 2851285..2851821 - 537 WP_210897574.1 hypothetical protein -
G127AT_RS13105 (G127AT_13105) 2852186..2852419 + 234 WP_210897576.1 Arc family DNA-binding protein Antitoxin
G127AT_RS13110 (G127AT_13110) 2852416..2852841 + 426 WP_210897579.1 type II toxin-antitoxin system VapC family toxin Toxin
G127AT_RS13115 (G127AT_13115) 2853071..2853457 + 387 WP_210897551.1 VOC family protein -
G127AT_RS13120 (G127AT_13120) 2853609..2854109 + 501 WP_210897581.1 hypothetical protein -
G127AT_RS13125 (G127AT_13125) 2854220..2854501 + 282 WP_210897583.1 type II toxin-antitoxin system RelE/ParE family toxin -
G127AT_RS13130 (G127AT_13130) 2854476..2854796 + 321 WP_210897585.1 HigA family addiction module antitoxin -
G127AT_RS16160 2854816..2854950 - 135 WP_244857997.1 hypothetical protein -
G127AT_RS16165 2855154..2855429 + 276 WP_244857573.1 hypothetical protein -
G127AT_RS13140 (G127AT_13140) 2855502..2856920 - 1419 WP_210897587.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2834838..2854992 20154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(12-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15021.04 Da        Isoelectric Point: 4.7523

>T196732 WP_210897579.1 NZ_CP071696:2852416-2852841 [Agromyces archimandritae]
MIVLDTNVISEIFRPSPEPRVVEWLASLTGDVAITAITLAELLAGVRRLPDGRRKDELAHGIEEAVALYRGSRSVLAFDT
GAAERYAEVLASREAAGAPVSTADAQIAAICLAHGATCATRNVKDFQHTGVELVDPWNVNA

Download         Length: 426 bp

>T196732 NZ_CP095276:c1088891-1088673 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8343.45 Da        Isoelectric Point: 5.6016

>AT196732 WP_210897576.1 NZ_CP071696:2852186-2852419 [Agromyces archimandritae]
VSSIIVRGLDDHVKEQLASQAKEHGRSMEAEVRDILTKAARRPHIGMALLAVARDVGGADELPIPTRDDVARAADFE

Download         Length: 234 bp

>AT196732 NZ_CP095276:c1089293-1088919 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References