Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1650953..1651578 Replicon chromosome
Accession NZ_CP071696
Organism Agromyces archimandritae strain G127AT

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G127AT_RS07410 Protein ID WP_210901515.1
Coordinates 1650953..1651330 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G127AT_RS07415 Protein ID WP_210901517.1
Coordinates 1651327..1651578 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G127AT_RS07395 (G127AT_07400) 1646728..1647954 + 1227 WP_210901511.1 acyl-CoA dehydrogenase family protein -
G127AT_RS07400 (G127AT_07405) 1648186..1649472 - 1287 WP_210901724.1 ISL3 family transposase -
G127AT_RS07405 (G127AT_07410) 1649680..1650909 + 1230 WP_210901513.1 acetyl-CoA C-acetyltransferase -
G127AT_RS07410 (G127AT_07415) 1650953..1651330 - 378 WP_210901515.1 type II toxin-antitoxin system VapC family toxin Toxin
G127AT_RS07415 (G127AT_07420) 1651327..1651578 - 252 WP_210901517.1 CopG family transcriptional regulator Antitoxin
G127AT_RS07420 (G127AT_07425) 1651639..1652658 - 1020 WP_210901519.1 amidohydrolase family protein -
G127AT_RS07425 (G127AT_07430) 1652641..1653210 + 570 WP_210901521.1 hypothetical protein -
G127AT_RS07430 (G127AT_07435) 1653211..1653777 - 567 WP_210901524.1 TetR/AcrR family transcriptional regulator -
G127AT_RS07435 (G127AT_07440) 1653888..1656374 + 2487 WP_210901526.1 MMPL family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13619.68 Da        Isoelectric Point: 5.1787

>T196731 WP_210901515.1 NZ_CP071696:c1651330-1650953 [Agromyces archimandritae]
MSILVDTSVLIDVLRGIPEAAGVLRDARADGPLHASEITRLEVLAGMRPREEAATRELLDVLNWRPVDDRIAEVAGELGR
AWLPGNRGIDSADLAIAATAIVLDARLFTRNVKHFPMFHGLTAPY

Download         Length: 378 bp

>T196731 NZ_CP095276:c309374-309072 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGACAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9028.86 Da        Isoelectric Point: 4.1861

>AT196731 WP_210901517.1 NZ_CP071696:c1651578-1651327 [Agromyces archimandritae]
MLRTQISLTDEDRALLDAEAARTGRSISALIRDAVERTYGSASDVDEDIEAIDRAFGAWQDRDIDGAAYVEGLRSGDRLA
GAR

Download         Length: 252 bp

>AT196731 NZ_CP095276:c309065-308778 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References