Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 142529..143054 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP071694 | ||
| Organism | Salmonella sp. SAL-045 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | J1G49_RS23385 | Protein ID | WP_001159863.1 |
| Coordinates | 142529..142834 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | J1G49_RS23390 | Protein ID | WP_000813641.1 |
| Coordinates | 142836..143054 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J1G49_RS23345 | 137908..138468 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| J1G49_RS23350 | 138624..138911 | + | 288 | WP_071530243.1 | hypothetical protein | - |
| J1G49_RS23355 | 139188..139673 | - | 486 | WP_000905606.1 | membrane protein | - |
| J1G49_RS23360 | 139667..140176 | - | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| J1G49_RS23365 | 140180..140893 | - | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| J1G49_RS23370 | 140902..141684 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| J1G49_RS23375 | 141719..142240 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| J1G49_RS23380 | 142237..142527 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| J1G49_RS23385 | 142529..142834 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| J1G49_RS23390 | 142836..143054 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| J1G49_RS23395 | 143730..144251 | + | 522 | WP_077681952.1 | hypothetical protein | - |
| J1G49_RS23400 | 144295..144723 | - | 429 | Protein_154 | hypothetical protein | - |
| J1G49_RS23405 | 144735..145030 | + | 296 | Protein_155 | cytoplasmic protein | - |
| J1G49_RS23410 | 145524..146513 | + | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| J1G49_RS23415 | 146840..147001 | - | 162 | WP_015059604.1 | hypothetical protein | - |
| J1G49_RS23420 | 147054..147440 | - | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / ant(3'')-Ia / lnu(F) / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / aph(4)-Ia / aac(3)-IVa / sul3 / cmlA1 / aadA2 / floR / dfrA14 / blaOXA-10 / ARR-3 / qnrS1 / tet(A) | spvB / spvC / pefB / pefA / pefC / pefD / rck | 1..318041 | 318041 | |
| - | flank | IS/Tn | - | - | 137491..137841 | 350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T196730 WP_001159863.1 NZ_CP071694:c142834-142529 [Salmonella sp. SAL-045]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T196730 NZ_CP095276:c309065-308778 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT196730 WP_000813641.1 NZ_CP071694:c143054-142836 [Salmonella sp. SAL-045]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT196730 NZ_CP095276:c309374-309072 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGACAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGACAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |