Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988504..989318 Replicon chromosome
Accession NZ_CP071693
Organism Salmonella sp. SAL-045

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag J1G49_RS04725 Protein ID WP_000971655.1
Coordinates 988504..989031 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag J1G49_RS04730 Protein ID WP_000855694.1
Coordinates 989028..989318 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G49_RS04695 984793..985191 + 399 Protein_919 cytoplasmic protein -
J1G49_RS04700 985402..985569 + 168 Protein_920 transposase -
J1G49_RS04705 985777..986445 + 669 WP_000445914.1 hypothetical protein -
J1G49_RS04710 986472..986966 + 495 WP_000424949.1 hypothetical protein -
J1G49_RS04715 987211..987867 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
J1G49_RS04720 988208..988431 + 224 Protein_924 IS5/IS1182 family transposase -
J1G49_RS04725 988504..989031 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
J1G49_RS04730 989028..989318 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
J1G49_RS04735 989588..989777 - 190 Protein_927 IS3 family transposase -
J1G49_RS04740 990181..990624 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
J1G49_RS04745 991080..991730 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
J1G49_RS04750 991727..993415 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 988255..988431 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T196708 WP_000971655.1 NZ_CP071693:c989031-988504 [Salmonella sp. SAL-045]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T196708 NZ_CP095271:1040479-1040814 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT196708 WP_000855694.1 NZ_CP071693:c989318-989028 [Salmonella sp. SAL-045]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT196708 NZ_CP095271:1040231-1040479 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References