Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825017..825677 Replicon chromosome
Accession NZ_CP071693
Organism Salmonella sp. SAL-045

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag J1G49_RS03975 Protein ID WP_000244756.1
Coordinates 825264..825677 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag J1G49_RS03970 Protein ID WP_000351186.1
Coordinates 825017..825283 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G49_RS03950 820946..822379 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
J1G49_RS03955 822537..822848 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
J1G49_RS03960 823012..823671 + 660 WP_000250289.1 hemolysin III family protein -
J1G49_RS03965 823787..824767 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
J1G49_RS03970 825017..825283 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
J1G49_RS03975 825264..825677 + 414 WP_000244756.1 protein YgfX Toxin
J1G49_RS03980 825730..826251 - 522 WP_001055885.1 flavodoxin FldB -
J1G49_RS03985 826364..827260 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
J1G49_RS03990 827284..827997 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J1G49_RS03995 828003..829736 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T196706 WP_000244756.1 NZ_CP071693:825264-825677 [Salmonella sp. SAL-045]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T196706 NZ_CP095271:178593-178700 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT196706 WP_000351186.1 NZ_CP071693:825017-825283 [Salmonella sp. SAL-045]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196706 NZ_CP095271:c178536-178479 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References