Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200168..200928 Replicon chromosome
Accession NZ_CP071693
Organism Salmonella sp. SAL-045

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag J1G49_RS00930 Protein ID WP_000533912.1
Coordinates 200443..200928 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag J1G49_RS00925 Protein ID WP_000965886.1
Coordinates 200168..200455 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G49_RS00905 195573..196484 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
J1G49_RS00910 196494..198563 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
J1G49_RS00915 199160..199351 + 192 WP_001541099.1 IS3 family transposase -
J1G49_RS00920 199523..199990 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
J1G49_RS00925 200168..200455 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
J1G49_RS00930 200443..200928 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
J1G49_RS00935 201299..201838 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
J1G49_RS00940 202012..202224 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
J1G49_RS00945 202512..202802 - 291 WP_000455790.1 HTH-type transcriptional regulator -
J1G49_RS00950 203241..203951 + 711 WP_000190524.1 DUF3053 domain-containing protein -
J1G49_RS00955 204001..204975 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
J1G49_RS00960 205194..205856 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T196703 WP_000533912.1 NZ_CP071693:200443-200928 [Salmonella sp. SAL-045]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T196703 NZ_CP095268:c2534-2268 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT196703 WP_000965886.1 NZ_CP071693:200168-200455 [Salmonella sp. SAL-045]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT196703 NZ_CP095268:c2742-2518 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References