Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179513..4180294 Replicon chromosome
Accession NZ_CP071690
Organism Salmonella sp. SAL-020

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag J1G48_RS20350 Protein ID WP_000626100.1
Coordinates 4179513..4180004 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag J1G48_RS20355 Protein ID WP_001110452.1
Coordinates 4180001..4180294 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G48_RS20320 4174973..4175320 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
J1G48_RS20325 4175296..4176999 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
J1G48_RS20330 4177036..4177611 + 576 WP_001188509.1 transcriptional regulator -
J1G48_RS20340 4177882..4177956 - 75 Protein_3974 helix-turn-helix domain-containing protein -
J1G48_RS20345 4178513..4179265 + 753 WP_000842433.1 non-specific acid phosphatase -
J1G48_RS20350 4179513..4180004 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
J1G48_RS20355 4180001..4180294 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
J1G48_RS20360 4180611..4180832 + 222 WP_001576552.1 hypothetical protein -
J1G48_RS20365 4181098..4181973 + 876 WP_000921676.1 AraC family transcriptional regulator -
J1G48_RS20370 4181970..4182257 + 288 WP_001541332.1 GerE family regulatory protein -
J1G48_RS20375 4182250..4182558 - 309 WP_072095651.1 ATP-binding cassette domain-containing protein -
J1G48_RS20380 4182494..4182829 + 336 WP_000370528.1 hypothetical protein -
J1G48_RS20385 4183342..4184247 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T196700 WP_000626100.1 NZ_CP071690:c4180004-4179513 [Salmonella sp. SAL-020]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T196700 NZ_CP095265:132779-132928 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT196700 WP_001110452.1 NZ_CP071690:c4180294-4180001 [Salmonella sp. SAL-020]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT196700 NZ_CP095265:c132734-132675 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References