Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072617..4073133 Replicon chromosome
Accession NZ_CP071690
Organism Salmonella sp. SAL-020

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag J1G48_RS19785 Protein ID WP_000220582.1
Coordinates 4072617..4072901 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag J1G48_RS19790 Protein ID WP_000212724.1
Coordinates 4072891..4073133 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G48_RS19770 4067828..4069480 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
J1G48_RS19775 4069889..4072027 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
J1G48_RS19780 4072149..4072613 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J1G48_RS19785 4072617..4072901 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G48_RS19790 4072891..4073133 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J1G48_RS19795 4073211..4075124 - 1914 WP_001212142.1 BglG family transcription antiterminator -
J1G48_RS19800 4075141..4075881 - 741 WP_000779259.1 KDGP aldolase family protein -
J1G48_RS19805 4075878..4076996 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
J1G48_RS19810 4076980..4078113 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T196699 WP_000220582.1 NZ_CP071690:c4072901-4072617 [Salmonella sp. SAL-020]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T196699 NZ_CP095264:c5393289-5392906 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT196699 WP_000212724.1 NZ_CP071690:c4073133-4072891 [Salmonella sp. SAL-020]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT196699 NZ_CP095264:c5393531-5393289 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References