Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031237..4031787 Replicon chromosome
Accession NZ_CP071686
Organism Salmonella sp. SAL-007

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag J1G46_RS19585 Protein ID WP_001199743.1
Coordinates 4031237..4031545 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag J1G46_RS19590 Protein ID WP_001118105.1
Coordinates 4031548..4031787 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G46_RS19565 4027811..4028551 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
J1G46_RS19570 4028673..4029170 - 498 WP_001679247.1 SEF14 fimbria major subunit SefA -
J1G46_RS19575 4029526..4030659 + 1134 Protein_3826 IS3 family transposase -
J1G46_RS19580 4030691..4030831 - 141 Protein_3827 DUF4102 domain-containing protein -
J1G46_RS19585 4031237..4031545 - 309 WP_001199743.1 CcdB family protein Toxin
J1G46_RS19590 4031548..4031787 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J1G46_RS19595 4031896..4032144 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
J1G46_RS19600 4032335..4032820 - 486 Protein_3831 helix-turn-helix domain-containing protein -
J1G46_RS19610 4033523..4034542 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
J1G46_RS19615 4034570..4035100 - 531 WP_000896758.1 gluconokinase -
J1G46_RS19620 4035317..4036348 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029618..4032721 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T196672 WP_001199743.1 NZ_CP071686:c4031545-4031237 [Salmonella sp. SAL-007]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T196672 NZ_CP095253:c1697060-1696527 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT196672 WP_001118105.1 NZ_CP071686:c4031787-4031548 [Salmonella sp. SAL-007]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT196672 NZ_CP095253:c1697337-1697071 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References