Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411447..3412067 Replicon chromosome
Accession NZ_CP071686
Organism Salmonella sp. SAL-007

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag J1G46_RS16715 Protein ID WP_001280991.1
Coordinates 3411849..3412067 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag J1G46_RS16710 Protein ID WP_000344807.1
Coordinates 3411447..3411821 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G46_RS16700 3406586..3407779 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J1G46_RS16705 3407802..3410951 + 3150 WP_001132508.1 multidrug efflux RND transporter permease subunit -
J1G46_RS16710 3411447..3411821 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
J1G46_RS16715 3411849..3412067 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
J1G46_RS16720 3412246..3412797 + 552 WP_001278793.1 maltose O-acetyltransferase -
J1G46_RS16725 3412915..3413385 + 471 WP_000136183.1 membrane protein -
J1G46_RS16730 3413441..3413581 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
J1G46_RS16735 3413587..3413847 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
J1G46_RS16740 3414072..3415622 + 1551 WP_000213140.1 EAL domain-containing protein -
J1G46_RS16750 3415853..3416242 + 390 WP_000961287.1 MGMT family protein -
J1G46_RS16755 3416275..3416844 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T196667 WP_001280991.1 NZ_CP071686:3411849-3412067 [Salmonella sp. SAL-007]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T196667 NZ_CP095248:45822-46133 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT196667 WP_000344807.1 NZ_CP071686:3411447-3411821 [Salmonella sp. SAL-007]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT196667 NZ_CP095248:46130-46549 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References