Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835941..836566 Replicon chromosome
Accession NZ_CP071686
Organism Salmonella sp. SAL-007

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag J1G46_RS04040 Protein ID WP_000911336.1
Coordinates 836168..836566 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag J1G46_RS04035 Protein ID WP_000557549.1
Coordinates 835941..836168 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G46_RS04005 830949..832466 + 1518 WP_000003339.1 lysine--tRNA ligase -
J1G46_RS04010 832542..833087 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
J1G46_RS04015 833352..834110 + 759 WP_000244328.1 peptidoglycan DD-metalloendopeptidase family protein -
J1G46_RS04025 834395..835201 - 807 WP_001574939.1 DUF1460 domain-containing protein -
J1G46_RS04030 835481..835732 - 252 WP_001576352.1 hypothetical protein -
J1G46_RS04035 835941..836168 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
J1G46_RS04040 836168..836566 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
J1G46_RS04045 837374..837910 + 537 WP_001038502.1 STM3031 family outer membrane protein -
J1G46_RS04050 837957..838589 + 633 WP_000835265.1 YfdX family protein -
J1G46_RS04055 839308..839889 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 834395..845750 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T196655 WP_000911336.1 NZ_CP071686:836168-836566 [Salmonella sp. SAL-007]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T196655 NZ_CP095247:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT196655 WP_000557549.1 NZ_CP071686:835941-836168 [Salmonella sp. SAL-007]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT196655 NZ_CP095247:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References