Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 395276..395943 Replicon plasmid p1
Accession NZ_CP071633
Organism Rhizobium sp. NZLR1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3O30_RS24305 Protein ID WP_207585122.1
Coordinates 395533..395943 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3O30_RS24300 Protein ID WP_207585121.1
Coordinates 395276..395536 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3O30_RS24270 390589..392112 - 1524 WP_207585117.1 AMP-binding protein -
J3O30_RS24275 392141..392551 - 411 WP_207585118.1 thioesterase family protein -
J3O30_RS24280 392605..393573 + 969 WP_207585119.1 zinc-binding dehydrogenase -
J3O30_RS24285 393614..393832 - 219 Protein_383 response regulator -
J3O30_RS24290 393833..394427 - 595 Protein_384 sensor histidine kinase -
J3O30_RS24295 394572..395027 + 456 WP_207585120.1 SgcJ/EcaC family oxidoreductase -
J3O30_RS24300 395276..395536 + 261 WP_207585121.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J3O30_RS24305 395533..395943 + 411 WP_207585122.1 PIN domain-containing protein Toxin
J3O30_RS24310 396021..398207 - 2187 WP_207585123.1 catalase/peroxidase HPI -
J3O30_RS24315 398349..399263 + 915 WP_207585124.1 LysR family transcriptional regulator -
J3O30_RS24320 399277..400098 - 822 WP_207585125.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / htpB 1..913960 913960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14882.14 Da        Isoelectric Point: 5.2060

>T196637 WP_207585122.1 NZ_CP071633:395533-395943 [Rhizobium sp. NZLR1]
VITHLVDTNAVIALIGRKSDILLSRVIESDEGSIGLSTIVMHELYYGAYGSAKISYNLETLRLFMADFPAIGFEREDALA
AGEIRAALAAKGRPIGPYDVLIAAQAKARDLFVITNNVGEFRRVDGLRVEDWMVGR

Download         Length: 411 bp

>T196637 NZ_CP095238:c2927-2613 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9938.03 Da        Isoelectric Point: 5.1409

>AT196637 WP_207585121.1 NZ_CP071633:395276-395536 [Rhizobium sp. NZLR1]
MPQYARVFQSGNSQAVRLPKEFRFDVDQVEVTREGDAIILRPRTDHGRRWASLQSALERGFSDDFMAEGRGQPEDQERPG
LQDLFK

Download         Length: 261 bp

>AT196637 NZ_CP095238:c3193-2915 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References