Detailed information of TA system TA196634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1116355..1116832
• Replicon: chromosome
• Accession: NZ_CP071632
• Organism: Rhizobium sp. NZLR1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: J3O30_RS05525
• Protein ID: WP_183696222.1
• Coordinates: 1116563..1116832 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: J3O30_RS05520
• Protein ID: WP_207583263.1
• Coordinates: 1116355..1116579 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3O30_RS05490	1111480..1112115	+	636	WP_207583257.1	hypothetical protein	-
J3O30_RS05495	1112327..1113469	+	1143	WP_207583258.1	site-specific DNA-methyltransferase	-
J3O30_RS05500	1113588..1113953	-	366	WP_207583259.1	nuclear transport factor 2 family protein	-
J3O30_RS05505	1113958..1114572	-	615	WP_207583260.1	HAD-IA family hydrolase	-
J3O30_RS05510	1114575..1115678	-	1104	WP_207583261.1	A/G-specific adenine glycosylase	-
J3O30_RS05515	1115787..1116284	+	498	WP_207583262.1	DUF721 domain-containing protein	-
J3O30_RS05520	1116355..1116579	+	225	WP_207583263.1	TraY domain-containing protein	Antitoxin
J3O30_RS05525	1116563..1116832	+	270	WP_183696222.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3O30_RS05530	1116982..1117758	+	777	WP_207583264.1	thioredoxin domain-containing protein	-
J3O30_RS05535	1117861..1121322	+	3462	WP_207583265.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10478.04 Da
• Isoelectric Point: 10.0802

>T196634 WP_183696222.1 NZ_CP071632:1116563-1116832 [Rhizobium sp. NZLR1]
MVWRIEFHRAAERELEKLGHEAARRILRFLNDRVARLDDPRSIGEALKGSELGDFWKYRVGDYRVIANIDDGAVLILIVR
IGNRRDVYR

Nucleotide

• Length: 270 bp

>T196634 NZ_CP095235:c134615-134199 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8545.74 Da
• Isoelectric Point: 4.8782

>AT196634 WP_207583263.1 NZ_CP071632:1116355-1116579 [Rhizobium sp. NZLR1]
MLALRLPPDIEARLDELAKRTGRSKSFYARQAILEHLDDLEDIYLAEKRLEELRRGESDSVPLAELMARHGLEN

Nucleotide

• Length: 225 bp

>AT196634 NZ_CP095235:c134842-134612 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA