Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 237876..238552 Replicon plasmid p1
Accession NZ_CP071627
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3P71_RS27285 Protein ID WP_168302594.1
Coordinates 237876..238301 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3P71_RS27290 Protein ID WP_131663397.1
Coordinates 238298..238552 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS27265 233215..233874 - 660 WP_168302590.1 sigma-70 family RNA polymerase sigma factor -
J3P71_RS27270 234037..234528 + 492 WP_168302591.1 GNAT family N-acetyltransferase -
J3P71_RS27275 234609..235391 - 783 WP_168302592.1 siderophore-iron reductase FhuF -
J3P71_RS27280 235401..237584 - 2184 WP_168302593.1 TonB-dependent siderophore receptor -
J3P71_RS27285 237876..238301 - 426 WP_168302594.1 type II toxin-antitoxin system VapC family toxin Toxin
J3P71_RS27290 238298..238552 - 255 WP_131663397.1 plasmid stabilization protein Antitoxin
J3P71_RS27295 238916..240133 + 1218 WP_168302595.1 GGDEF domain-containing protein -
J3P71_RS27300 240285..241028 + 744 WP_168302596.1 FadR family transcriptional regulator -
J3P71_RS27305 241012..242610 + 1599 WP_168302597.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..669795 669795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15248.53 Da        Isoelectric Point: 5.1351

>T196631 WP_168302594.1 NZ_CP071627:c238301-237876 [Rhizobium leguminosarum]
MILIDTNVISEPWKPTPDNQVLAWIDAQAVETLFVSAITVAELRFGIAAMPSGRRKTVLYDRLEQEVLPLFSGRVLSFDM
AASQSYSELMARARVAGRAIGKADAYIAATAAANGFIVATRDTSPFEAAGLGVINPWFART

Download         Length: 426 bp

>T196631 NZ_CP095234:3230400-3230807 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9237.42 Da        Isoelectric Point: 5.6228

>AT196631 WP_131663397.1 NZ_CP071627:c238552-238298 [Rhizobium leguminosarum]
MAAVTIRNLSEETHRALRVRAAHHGRSTEAEIRDILETAVRPAERVMLGSLLASIGREAGLSNDDVDNLQLVRDKTAAEP
MSFE

Download         Length: 255 bp

>AT196631 NZ_CP095234:3230153-3230419 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References