Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 56071..56762 Replicon plasmid p1
Accession NZ_CP071627
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3P71_RS26440 Protein ID WP_168305044.1
Coordinates 56071..56499 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3P71_RS26445 Protein ID WP_168305045.1
Coordinates 56496..56762 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS26405 51616..52263 + 648 WP_168305043.1 TetR/AcrR family transcriptional regulator -
J3P71_RS26410 52269..52621 + 353 Protein_50 flagellar protein -
J3P71_RS26415 52608..52803 + 196 Protein_51 hypothetical protein -
J3P71_RS26420 52968..53807 + 840 WP_020047059.1 transporter substrate-binding domain-containing protein -
J3P71_RS26425 53921..54583 + 663 WP_026264480.1 amino acid ABC transporter permease -
J3P71_RS26430 54588..55247 + 660 WP_020047057.1 amino acid ABC transporter permease -
J3P71_RS26435 55260..56030 + 771 WP_020047056.1 amino acid ABC transporter ATP-binding protein -
J3P71_RS26440 56071..56499 - 429 WP_168305044.1 type II toxin-antitoxin system VapC family toxin Toxin
J3P71_RS26445 56496..56762 - 267 WP_168305045.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J3P71_RS26450 57017..57778 + 762 WP_168305046.1 GntR family transcriptional regulator -
J3P71_RS26455 57772..58557 + 786 WP_168305047.1 transporter substrate-binding domain-containing protein -
J3P71_RS26460 58637..59308 + 672 WP_020047052.1 amino acid ABC transporter permease -
J3P71_RS26465 59305..59964 + 660 WP_017956570.1 amino acid ABC transporter permease -
J3P71_RS26470 59942..60667 + 726 WP_012755581.1 amino acid ABC transporter ATP-binding protein -
J3P71_RS26475 60931..61302 - 372 WP_168267438.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3P71_RS26480 61302..61559 - 258 WP_003550229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..669795 669795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-66)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15706.89 Da        Isoelectric Point: 4.6492

>T196629 WP_168305044.1 NZ_CP071627:c56499-56071 [Rhizobium leguminosarum]
VRLLLDTNVLSEVTRPRPDAHVLQWLDSLDEDRSFISTVSIAEIRRGVALMGSGRKRDALAEWLAQDLPQRFEQRVIPVD
QPVAIAWGDLTGLAERSGRGLSSMDGLIAGTAIAHDLILATRNIKDFEGLGIELVDPWTERP

Download         Length: 429 bp

>T196629 NZ_CP095234:2706408-2706755 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10019.41 Da        Isoelectric Point: 10.4689

>AT196629 WP_168305045.1 NZ_CP071627:c56762-56496 [Rhizobium leguminosarum]
MQPSRSEDKRWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLRGADLDLERQR
DEPRDLQL

Download         Length: 267 bp

>AT196629 NZ_CP095234:2706755-2707054 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References