Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5077366..5077898 Replicon chromosome
Accession NZ_CP071626
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J3P71_RS25030 Protein ID WP_168303380.1
Coordinates 5077366..5077656 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag J3P71_RS25035 Protein ID WP_168303379.1
Coordinates 5077653..5077898 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS25005 5073358..5073789 + 432 WP_168268488.1 hypothetical protein -
J3P71_RS25010 5073857..5074498 - 642 WP_168303384.1 LysE family translocator -
J3P71_RS25015 5074722..5075096 - 375 WP_168303383.1 helix-turn-helix transcriptional regulator -
J3P71_RS25020 5075181..5075798 + 618 WP_168303382.1 NAD(P)H-dependent oxidoreductase -
J3P71_RS25025 5076037..5077260 - 1224 WP_168303381.1 argininosuccinate synthase -
J3P71_RS25030 5077366..5077656 - 291 WP_168303380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3P71_RS25035 5077653..5077898 - 246 WP_168303379.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J3P71_RS25040 5077986..5078837 + 852 WP_168303378.1 SDR family NAD(P)-dependent oxidoreductase -
J3P71_RS25045 5079028..5079669 + 642 WP_168303377.1 LysE family translocator -
J3P71_RS25050 5079717..5080511 - 795 WP_168303376.1 ABC transporter ATP-binding protein -
J3P71_RS25055 5080508..5081386 - 879 WP_168303375.1 ABC transporter permease -
J3P71_RS25060 5081509..5082462 - 954 WP_168303374.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10949.61 Da        Isoelectric Point: 8.0410

>T196627 WP_168303380.1 NZ_CP071626:c5077656-5077366 [Rhizobium leguminosarum]
MKALVLSPAAVDDLDRIYDYTEEKWGQGQAEDYIVALRDDCEALAAQTKRGRRIIGLRSGYTALAFRSHFVIYAETEKVL
TVIRILHRRMNIAAHL

Download         Length: 291 bp

>T196627 NZ_CP095234:c2273656-2273273 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8987.03 Da        Isoelectric Point: 4.4179

>AT196627 WP_168303379.1 NZ_CP071626:c5077898-5077653 [Rhizobium leguminosarum]
VAKVVSIRIDDHMEEFIGNQLDQGTYGSADEVIDAGLRLLQREAELAAIEAAIIEGEKSGEPRPFDFDAFIEGKRARRGR
Q

Download         Length: 246 bp

>AT196627 NZ_CP095234:c2273898-2273656 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References