Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2706493..2706908 Replicon chromosome
Accession NZ_CP071626
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3P71_RS13635 Protein ID WP_205936953.1
Coordinates 2706717..2706908 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3P71_RS13630 Protein ID WP_168304368.1
Coordinates 2706493..2706720 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS13605 2701908..2702732 - 825 WP_168304364.1 inositol monophosphatase family protein -
J3P71_RS13610 2702773..2703600 - 828 WP_168304365.1 inositol monophosphatase family protein -
J3P71_RS13615 2703648..2704517 - 870 WP_168304366.1 tRNA 2-thiocytidine(32) synthetase TtcA -
J3P71_RS13620 2704578..2705507 - 930 WP_168304367.1 glutaminase -
J3P71_RS13625 2705610..2706227 - 618 WP_017964499.1 30S ribosomal protein S4 -
J3P71_RS13630 2706493..2706720 + 228 WP_168304368.1 CopG family transcriptional regulator Antitoxin
J3P71_RS13635 2706717..2706908 + 192 WP_205936953.1 hypothetical protein Toxin
J3P71_RS13640 2706920..2708431 - 1512 WP_168304369.1 ATP-binding protein -
J3P71_RS13645 2708571..2709014 - 444 WP_168304370.1 GNAT family N-acetyltransferase -
J3P71_RS13650 2709093..2709275 - 183 WP_168304371.1 DUF1778 domain-containing protein -
J3P71_RS13655 2709331..2710131 - 801 WP_168304372.1 glutamate racemase -
J3P71_RS13660 2710112..2710942 - 831 WP_168304373.1 RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7254.31 Da        Isoelectric Point: 7.3586

>T196624 WP_205936953.1 NZ_CP071626:2706717-2706908 [Rhizobium leguminosarum]
VTFLFDVNVLIALFDPHHLYHEPAHRWFRSLDRDSWATCPLTENGVARILGKSKLPGFAWFSG

Download         Length: 192 bp

>T196624 NZ_CP095234:c1688724-1688191 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8647.83 Da        Isoelectric Point: 4.8411

>AT196624 WP_168304368.1 NZ_CP071626:2706493-2706720 [Rhizobium leguminosarum]
MKTTLAIDDDVLDAAREIAERQEKNLGEVISDLARRSLEMQQLAPRRNGVPLIKRKPTDRTITPEFVNELRDEYP

Download         Length: 228 bp

>AT196624 NZ_CP095234:c1689001-1688735 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References