Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1308981..1310470 Replicon chromosome
Accession NZ_CP071626
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag J3P71_RS06455 Protein ID WP_168306929.1
Coordinates 1308981..1310243 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag J3P71_RS06460 Protein ID WP_038613852.1
Coordinates 1310240..1310470 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS06430 1304938..1305645 + 708 WP_168306924.1 hypothetical protein -
J3P71_RS06435 1305645..1306751 + 1107 WP_168306925.1 DNA (cytosine-5-)-methyltransferase -
J3P71_RS06440 1306743..1306988 - 246 WP_168306926.1 hypothetical protein -
J3P71_RS06445 1307117..1307737 + 621 WP_168306927.1 hypothetical protein -
J3P71_RS06450 1307776..1308555 - 780 WP_168306928.1 SDR family NAD(P)-dependent oxidoreductase -
J3P71_RS06455 1308981..1310243 - 1263 WP_168306929.1 type II toxin-antitoxin system HipA family toxin Toxin
J3P71_RS06460 1310240..1310470 - 231 WP_038613852.1 helix-turn-helix transcriptional regulator Antitoxin
J3P71_RS06465 1310928..1311536 - 609 WP_168307044.1 TetR/AcrR family transcriptional regulator -
J3P71_RS06470 1311649..1312335 + 687 WP_168307043.1 PspA/IM30 family protein -
J3P71_RS06475 1312377..1312658 + 282 WP_003546080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45464.29 Da        Isoelectric Point: 6.0149

>T196622 WP_168306929.1 NZ_CP071626:c1310243-1308981 [Rhizobium leguminosarum]
MTSRLLNVWWDGRIVGQFTQDRHGDIGFVYARAWLDDDKTLPLSASLPKRPERFTRQECRPFFAGLLPEESQRLAAARAL
GVSPANDFALLDHLGGDVAGALQLLAEGEAPAETASIADRQPVPLDEAGIVGVLEALPVRPLLAGEEGLRLSLAGAQSKL
PVVLIDGRIGLPLPGQATTHILKPPIARFKATTENEAFVMRLAAAIGLDVAAVEPRYVQGRPFLLVERYDRVRGAGGLVH
RIHQEDFCQALSVPPETKYASEGGPTFKDCFDLIRRISARPAVDVLKLLDAAIFNLIAGNADAHGKNFSILYDSQGPRLA
RLYDLLSTVIYPELSPRLAMRLGKRATLAEMDAEGWKAFAAEAGVGTPLLRRRLNELCDKVLTLTGKVADELADVSPDRG
PIDAIAGVITDRAETARLTL

Download         Length: 1263 bp

>T196622 NZ_CP095187:c3776939-3776745 [Pseudoxanthomonas sp. F37]
GTGCCACCCAAGATTCGCGATGTGTTGCAACAACTCAAGGACGCGGGCTGGCAGCAGGTGGGCCAGACCGGCAGCCACCG
GCAGTTCAAGCACCCCACGCTTCCAGGCCGCGTGACAGTCGCCGGCAAGCCGGGTGATGATGTGGCGCCCGGGACATTGG
CCAGCATCCTGAAGCAGGCCGGGATCAAGAGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8159.46 Da        Isoelectric Point: 9.3464

>AT196622 WP_038613852.1 NZ_CP071626:c1310470-1310240 [Rhizobium leguminosarum]
MPKHVQSPADIGALVRSTRKEQNLRQDELAGVAGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSLDILAPGERRQ

Download         Length: 231 bp

>AT196622 NZ_CP095187:c3776739-3776527 [Pseudoxanthomonas sp. F37]
ATGCGCTACGCCATCGTCATCGAGCAAGCTGGCGGCAACTATTCCGCGTATGTCCCGGACCTGCCGGGTTGCGTGGCCAC
CGGTGCCACCAAGGCCGAGGTGGAAGTACTGATCCACGACGCCATTGCGTTGCATCTGGCCGGATTGCGCGAGGACGGCG
TGGCCATTCCGGTGCCTTCGAGCCAGGTGGAGTACATCGACGTCGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References