Detailed information of TA system TA196605

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3240528..3241189
• Replicon: chromosome
• Accession: NZ_CP071602
• Organism: Bordetella parapertussis strain CIDM-BPP2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: J3Q23_RS15195
• Protein ID: WP_003812073.1
• Coordinates: 3240764..3241189 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J3Q23_RS15190
• Protein ID: WP_003812071.1
• Coordinates: 3240528..3240767 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q23_RS15155	3235563..3236366	-	804	WP_003812055.1	bacteriocin family protein	-
J3Q23_RS15160	3236363..3237409	-	1047	WP_010928022.1	Dyp-type peroxidase	-
J3Q23_RS15165	3237487..3238047	-	561	WP_010928021.1	DUF488 domain-containing protein	-
J3Q23_RS15170	3238044..3238277	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
J3Q23_RS15175	3238358..3238870	-	513	WP_003812062.1	redoxin domain-containing protein	-
J3Q23_RS15180	3238929..3239474	-	546	WP_010928020.1	peroxidase-related enzyme	-
J3Q23_RS15185	3239612..3240454	+	843	WP_010928019.1	AraC family transcriptional regulator	-
J3Q23_RS15190	3240528..3240767	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
J3Q23_RS15195	3240764..3241189	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
J3Q23_RS15200	3241299..3241763	+	465	WP_003812075.1	MarR family transcriptional regulator	-
J3Q23_RS15205	3241861..3243366	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
J3Q23_RS15210	3243865..3244377	+	513	WP_010928017.1	hypothetical protein	-
J3Q23_RS15215	3244398..3245375	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T196605 WP_003812073.1 NZ_CP071602:3240764-3241189 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T196605 NZ_CP095177:c3805350-3804940 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCATCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT196605 WP_003812071.1 NZ_CP071602:3240528-3240767 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT196605 NZ_CP095177:c3805597-3805331 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q7WAH5