Detailed information of TA system TA196604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2654005..2654536
• Replicon: chromosome
• Accession: NZ_CP071602
• Organism: Bordetella parapertussis strain CIDM-BPP2

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: J3Q23_RS12380
• Protein ID: WP_003812626.1
• Coordinates: 2654005..2654271 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: J3Q23_RS12385
• Protein ID: WP_003816743.1
• Coordinates: 2654258..2654536 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q23_RS12355	2649132..2649404	+	273	WP_003812615.1	hypothetical protein	-
J3Q23_RS12360	2649443..2650153	-	711	WP_003812617.1	aquaporin Z	-
J3Q23_RS12365	2650264..2650896	-	633	WP_003812619.1	PAS domain-containing protein	-
J3Q23_RS12370	2651293..2652171	+	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
J3Q23_RS12375	2652233..2653774	+	1542	WP_010928296.1	M81 family metallopeptidase	-
J3Q23_RS12380	2654005..2654271	+	267	WP_003812626.1	BrnT family toxin	Toxin
J3Q23_RS12385	2654258..2654536	+	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
J3Q23_RS12395	2654830..2655486	-	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
J3Q23_RS12400	2655501..2657168	-	1668	WP_010928294.1	TRAP transporter large permease subunit	-
J3Q23_RS12405	2657171..2657800	-	630	WP_010928293.1	TRAP transporter small permease subunit	-
J3Q23_RS12410	2658012..2659106	-	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T196604 WP_003812626.1 NZ_CP071602:2654005-2654271 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T196604 NZ_CP095177:3565598-3565897 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT196604 WP_003816743.1 NZ_CP071602:2654258-2654536 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT196604 NZ_CP095177:3565908-3566255 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCATGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTCGCCTGA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02