Detailed information of TA system TA196603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2519767..2520361
• Replicon: chromosome
• Accession: NZ_CP071602
• Organism: Bordetella parapertussis strain CIDM-BPP2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: J3Q23_RS11745
• Protein ID: WP_010928352.1
• Coordinates: 2519767..2519949 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: J3Q23_RS11750
• Protein ID: WP_010928351.1
• Coordinates: 2519972..2520361 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q23_RS11725	2514770..2515510	+	741	WP_003809659.1	carbonic anhydrase	-
J3Q23_RS11730	2515522..2516877	-	1356	WP_003809657.1	cytochrome c	-
J3Q23_RS11735	2516888..2518657	-	1770	WP_010928353.1	GMC family oxidoreductase	-
J3Q23_RS11740	2518661..2519359	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
J3Q23_RS11745	2519767..2519949	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
J3Q23_RS11750	2519972..2520361	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J3Q23_RS11760	2520627..2521403	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
J3Q23_RS11765	2521448..2522305	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
J3Q23_RS11770	2522327..2523343	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
J3Q23_RS11775	2523478..2524518	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T196603 WP_010928352.1 NZ_CP071602:2519767-2519949 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T196603 NZ_CP095177:3515771-3516100 [Enterobacter hormaechei]
ATGCAAACCATATCATCACACCCGACGCGGGCGACTCAGTCCTGCCTGTCACCCGTTGAAATCTGGCAGTTGCTGCTAAC
TCATCTGTTATCGCAGCACTATGGCCTGACACTGAATGACACACCATTCAATGATGAAACTACCATCCAGGAACATATTG
ATGCTGGAATATCACTCAGCGATGCGGTGAATTTTCTGGTAGAAAAATACGGGCTTGTCCGTATTGATCGGAAAGGATTT
TCGTGGCAAGAGCAGACCCCATATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCACTACCAGCTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT196603 WP_010928351.1 NZ_CP071602:2519972-2520361 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT196603 NZ_CP095177:3515367-3515765 [Enterobacter hormaechei]
ATGAACAATCACTCAGAATCCGGTACCAAGCCGGAGAATCCCGCCATCCAGCAGTGGGGACTGAAGCGCGATATAACACC
GTGTTTTGGCGCACGTCTGGTTCAGGAGGGCAACCGTCTGCATTATCTGGCTGACCGTGCAGGATTCAGCGGGGCGTGCA
CCAATGATGTTGCAATGCGCCTCGATCAGGCATTTCCGCTTATGATGAAACAACTTGAGCTGATGCTGACCAGCGGCGAG
CTTAACCCCCGCCATGCACATTGCGTCACGCTATACCACAACGGCCTCACATGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTACCCCCCTGCTTATTCCCTTAACATCTCAGAGTAA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7