Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2830817..2831614 Replicon chromosome
Accession NZ_CP071594
Organism Staphylococcus aureus strain PNID0137

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J3R87_RS14145 Protein ID WP_000525008.1
Coordinates 2831153..2831614 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag J3R87_RS14140 Protein ID WP_001260487.1
Coordinates 2830817..2831140 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R87_RS14080 (2826217) 2826217..2827005 - 789 WP_000134097.1 ATP-binding protein -
J3R87_RS14085 (2826998) 2826998..2827219 - 222 WP_000815403.1 DUF2483 family protein -
J3R87_RS14090 (2827229) 2827229..2827489 - 261 WP_000291090.1 DUF1108 family protein -
J3R87_RS14095 (2827586) 2827586..2827747 - 162 WP_000066011.1 DUF1270 domain-containing protein -
J3R87_RS14100 (2827740) 2827740..2827961 - 222 WP_000594789.1 hypothetical protein -
J3R87_RS14105 (2828032) 2828032..2828262 + 231 WP_000395455.1 hypothetical protein -
J3R87_RS14110 (2828453) 2828453..2828677 - 225 WP_000187184.1 hypothetical protein -
J3R87_RS14115 (2828678) 2828678..2829469 - 792 WP_001157019.1 phage antirepressor KilAC domain-containing protein -
J3R87_RS14120 (2829526) 2829526..2829765 + 240 WP_000438628.1 hypothetical protein -
J3R87_RS14125 (2829755) 2829755..2829934 - 180 WP_000393082.1 hypothetical protein -
J3R87_RS14130 (2829949) 2829949..2830392 - 444 WP_000435356.1 hypothetical protein -
J3R87_RS14135 (2830405) 2830405..2830653 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
J3R87_RS14140 (2830817) 2830817..2831140 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
J3R87_RS14145 (2831153) 2831153..2831614 + 462 WP_000525008.1 hypothetical protein Toxin
J3R87_RS14150 (2831798) 2831798..2832730 + 933 WP_000392183.1 hypothetical protein -
J3R87_RS14155 (2832710) 2832710..2832889 - 180 WP_000337827.1 hypothetical protein -
J3R87_RS14160 (2833002) 2833002..2834048 + 1047 WP_001145722.1 tyrosine-type recombinase/integrase -
J3R87_RS14165 (2834093) 2834093..2835238 + 1146 WP_029265169.1 radical SAM/CxCxxxxC motif protein YfkAB -
J3R87_RS14170 (2835498) 2835498..2836028 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2789257..2834048 44791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18034.35 Da        Isoelectric Point: 4.6899

>T196596 WP_000525008.1 NZ_CP071594:2831153-2831614 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T196596 NZ_CP095171:c50214-49798 [Enterobacter roggenkampii]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT196596 WP_001260487.1 NZ_CP071594:2830817-2831140 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT196596 NZ_CP095171:c50441-50211 [Enterobacter roggenkampii]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTAG
ACAGGGCCGATCCGGACTTTATGGCGCAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References