Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1628404..1628881 Replicon chromosome
Accession NZ_CP071594
Organism Staphylococcus aureus strain PNID0137

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag J3R87_RS07955 Protein ID WP_000052076.1
Coordinates 1628404..1628592 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag J3R87_RS07960 Protein ID WP_001059690.1
Coordinates 1628621..1628881 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R87_RS07925 (1624357) 1624357..1624914 + 558 WP_000824491.1 hypothetical protein -
J3R87_RS07930 (1625255) 1625255..1625941 + 687 WP_001574556.1 thermonuclease family protein -
J3R87_RS07935 (1626298) 1626298..1626498 + 201 WP_001059082.1 cold-shock protein -
J3R87_RS07940 (1626995) 1626995..1627213 - 219 WP_000005879.1 hypothetical protein -
J3R87_RS07945 (1627275) 1627275..1627559 - 285 WP_001004401.1 hypothetical protein -
J3R87_RS07950 (1627647) 1627647..1628216 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
J3R87_RS07955 (1628404) 1628404..1628592 - 189 WP_000052076.1 hypothetical protein Toxin
J3R87_RS07960 (1628621) 1628621..1628881 - 261 WP_001059690.1 hypothetical protein Antitoxin
J3R87_RS07965 (1629222) 1629222..1629425 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
J3R87_RS07970 (1629422) 1629422..1629658 - 237 WP_000368687.1 hypothetical protein -
J3R87_RS07975 (1629883) 1629883..1630464 + 582 WP_001140696.1 histidine phosphatase family protein -
J3R87_RS07980 (1630537) 1630537..1631154 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
J3R87_RS07985 (1631310) 1631310..1631804 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
J3R87_RS07990 (1632203) 1632203..1632625 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
J3R87_RS07995 (1632773) 1632773..1633489 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T196590 WP_000052076.1 NZ_CP071594:c1628592-1628404 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T196590 NZ_CP095170:1728195-1728716 [Enterobacter roggenkampii]
GTGGACAATCTCACGATCGAAATGTTTTCAGAGGGAAAAGACTATGATTTCAGGGACTTCGATTGTGGTGAACCCTCGCT
AAATGTCTTCCTCACAGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGGCTATTTGCTTAAAGATCGCGATG
GTCCGCGGGTCCTGGGCTATTACACGTTGTCTGGTAGTTGCTTTGAAAAAGCGATGCTGCCTTCTAAGACTCAGCAGCGT
CGGATCCCTTATAGCAACGTACCGAGCGTAACGCTGGGACGTCTGGCGATACATAAAGACTTACAGGGGCTGGAGTGGGG
AACGACGCTCGTCACGCATGCCATGCGGGTTGTCTATCTGGCATCGCAGGCGGTGGGGGTACACGGAATATTTGTTGATG
CACTCAACGACCAGGCAAAACAATTTTATCTGAAGCAGGGCTTTATTCCGCTGACGGATGAAAACAGCCATTCTCTTTTC
TTTCCTACAAAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT196590 WP_001059690.1 NZ_CP071594:c1628881-1628621 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT196590 NZ_CP095170:1727919-1728188 [Enterobacter roggenkampii]
ATGCCAGCACTGAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCAGCGGAAGTCATCGAGCAGCACCGCCGTC
TCGTATTAAACGAAGCATCCTGGAATGCGGTGATGGATGCCATCGACAATCCACCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References