Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 2404871..2405451 Replicon chromosome
Accession NZ_CP071589
Organism Staphylococcus simiae strain 17941E

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag J3R86_RS11140 Protein ID WP_207517353.1
Coordinates 2404871..2405206 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag J3R86_RS11145 Protein ID WP_207518556.1
Coordinates 2405203..2405451 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R86_RS11115 2400878..2401312 - 435 WP_207517343.1 MarR family transcriptional regulator -
J3R86_RS11120 2401502..2402425 - 924 WP_207517349.1 zinc ABC transporter substrate-binding protein -
J3R86_RS11125 2402621..2402902 + 282 WP_002463360.1 N-acetyltransferase -
J3R86_RS11130 2403157..2403966 + 810 WP_207517350.1 VOC family protein -
J3R86_RS11135 2404033..2404695 - 663 WP_207517352.1 nitroreductase family protein -
J3R86_RS11140 2404871..2405206 - 336 WP_207517353.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J3R86_RS11145 2405203..2405451 - 249 WP_207518556.1 AbrB family transcriptional regulator Antitoxin
J3R86_RS11150 2406186..2407178 + 993 WP_207517354.1 D-lactate dehydrogenase -
J3R86_RS11160 2408029..2409273 + 1245 WP_207517355.1 peptidoglycan bridge formation glycyltransferase FemA/FemB family protein -
J3R86_RS11165 2409419..2410219 - 801 WP_207517356.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12858.94 Da        Isoelectric Point: 8.9087

>T196577 WP_207517353.1 NZ_CP071589:c2405206-2404871 [Staphylococcus simiae]
MSVKQFDILYIDLDPTKGREKQKIQPCLVINNDMTIKGTNFVWILPITSREPKFPTDIEVKSKKRLVTGVIDTVQIRALN
LNAHEYNYRDELQDSLKNDVLLAINTFLKPQ

Download         Length: 336 bp

>T196577 NZ_CP095165:c277856-277569 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9394.71 Da        Isoelectric Point: 8.5410

>AT196577 WP_207518556.1 NZ_CP071589:c2405451-2405203 [Staphylococcus simiae]
INKTNERVFKSGNSKALSLSKQTLQLIHFEIGDKVEVQQMNDGIFIKKKEETIEDKITNFFKNGGKYIKSEIDFGESIGR
EI

Download         Length: 249 bp

>AT196577 NZ_CP095165:c278165-277863 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References