Detailed information of TA system TA196574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1819243..1820019
• Replicon: chromosome
• Accession: NZ_CP071589
• Organism: Staphylococcus simiae strain 17941E

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: J3R86_RS08225
• Protein ID: WP_207516908.1
• Coordinates: 1819243..1819398 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: J3R86_RS08230
• Protein ID: WP_207516909.1
• Coordinates: 1819420..1820019 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3R86_RS08205	1814550..1815671	-	1122	WP_207518538.1	GAF domain-containing protein	-
J3R86_RS08210	1815830..1816651	+	822	WP_207516905.1	RluA family pseudouridine synthase	-
J3R86_RS08215	1817122..1818507	-	1386	WP_207516906.1	class II fumarate hydratase	-
J3R86_RS08220	1818690..1819091	-	402	WP_207516907.1	hypothetical protein	-
J3R86_RS08225	1819243..1819398	-	156	WP_207516908.1	hypothetical protein	Toxin
J3R86_RS08230	1819420..1820019	-	600	WP_207516909.1	glucosamine-6-phosphate isomerase	Antitoxin
J3R86_RS08235	1820309..1820779	-	471	WP_207516910.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
J3R86_RS08240	1820781..1821911	-	1131	WP_207516911.1	tRNA epoxyqueuosine(34) reductase QueG	-
J3R86_RS08245	1822056..1822778	-	723	WP_207516912.1	ATP-binding cassette domain-containing protein	-
J3R86_RS08250	1822771..1824228	-	1458	WP_207516913.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (126-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6063.39 Da
• Isoelectric Point: 4.0406

>T196574 WP_207516908.1 NZ_CP071589:c1819398-1819243 [Staphylococcus simiae]
MVNEKDAKLNYHEDENAMVNDFDDLKELGKEMEQISEENDQEKHNQSHDNN

Nucleotide

• Length: 156 bp

>T196574 NZ_CP095164:137066-137416 [Edwardsiella anguillarum]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22616.61 Da
• Isoelectric Point: 4.8524

>AT196574 WP_207516909.1 NZ_CP071589:c1820019-1819420 [Staphylococcus simiae]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVDHHAVDFSQINILDYDNNQSYFEALGV
PKSQIYAIEFEKDAIEFISDKIKTKENKGKLTLQVLSISEQGHLDVSVRQGLMEAREIILVITGVNKREMVEKLYQENGK
SSYEPADLKAHRMVNVILDKEAAEGLPEDVKTYFTSRFA

Nucleotide

• Length: 600 bp

>AT196574 NZ_CP095164:137421-137723 [Edwardsiella anguillarum]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA