Detailed information of TA system TA196573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 6869..7787
• Replicon: plasmid pRM1477
• Accession: NZ_CP071588
• Organism: Campylobacter jejuni strain RM1477

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: J3Q14_RS08700
• Protein ID: WP_002907829.1
• Coordinates: 6869..7552 (-)
• Length: 228 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A3Z9GMV3
• Locus tag: J3Q14_RS08705
• Protein ID: WP_002907823.1
• Coordinates: 7545..7787 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q14_RS08655	2747..2971	-	225	WP_002907861.1	hypothetical protein	-
J3Q14_RS08660	2974..3660	-	687	WP_002907859.1	AAA family ATPase	-
J3Q14_RS08665	3741..4136	-	396	WP_002907857.1	conjugal transfer protein TraM	-
J3Q14_RS08670	4137..4679	-	543	WP_002907846.1	hypothetical protein	-
J3Q14_RS08675	4676..5179	-	504	WP_002907844.1	hypothetical protein	-
J3Q14_RS08680	5176..5571	-	396	WP_002907843.1	hypothetical protein	-
J3Q14_RS08685	5568..5891	-	324	WP_002907841.1	hypothetical protein	-
J3Q14_RS08690	5901..6308	-	408	WP_002907839.1	hypothetical protein	-
J3Q14_RS08695	6397..6864	-	468	WP_002907837.1	signal peptidase I	-
J3Q14_RS08700	6869..7552	-	684	WP_002907829.1	Fic family protein	Toxin
J3Q14_RS08705	7545..7787	-	243	WP_002907823.1	hypothetical protein	Antitoxin
J3Q14_RS08710	7879..8598	-	720	WP_002907820.1	conjugal transfer protein TraL	-
J3Q14_RS08715	8615..10438	-	1824	WP_002907817.1	type IV secretory system conjugative DNA transfer family protein	-
J3Q14_RS08720	10435..12648	-	2214	WP_002907814.1	DUF1738 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28220	28220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 228 a.a.
• Molecular weight: 26164.33 Da
• Isoelectric Point: 10.0750

>T196573 WP_002907829.1 NZ_CP071588:c7552-6869 [Campylobacter jejuni]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIYACAEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 684 bp

>T196573 NZ_CP095163:c3641769-3641353 [Edwardsiella anguillarum]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGACGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9276.49 Da
• Isoelectric Point: 4.3697

>AT196573 WP_002907823.1 NZ_CP071588:c7787-7545 [Campylobacter jejuni]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEGIKSVICGHAIEDMFANEKDVIDMIKIAKDEANADEIIAEYKREWGVND

Nucleotide

• Length: 243 bp

>AT196573 NZ_CP095163:c3642016-3641750 [Edwardsiella anguillarum]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Z9GMV3