Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 6155661..6156186 Replicon chromosome
Accession NZ_CP071586
Organism Pseudomonas germanica strain FIT28

Toxin (Protein)


Gene name relE Uniprot ID A0A7H8GF58
Locus tag J0G10_RS27300 Protein ID WP_016984129.1
Coordinates 6155890..6156186 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R7UU95
Locus tag J0G10_RS27295 Protein ID WP_016984130.1
Coordinates 6155661..6155900 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G10_RS27270 (J0G10_27290) 6151462..6151923 + 462 WP_220557050.1 GNAT family N-acetyltransferase -
J0G10_RS27275 (J0G10_27295) 6152153..6152803 + 651 WP_220557051.1 DedA family protein -
J0G10_RS27280 (J0G10_27300) 6152808..6153620 + 813 WP_095048798.1 zinc-dependent peptidase -
J0G10_RS27285 (J0G10_27305) 6153733..6154260 + 528 WP_008052339.1 inorganic diphosphatase -
J0G10_RS27290 (J0G10_27310) 6154484..6155230 + 747 WP_095048800.1 helix-turn-helix transcriptional regulator -
J0G10_RS27295 (J0G10_27315) 6155661..6155900 + 240 WP_016984130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J0G10_RS27300 (J0G10_27320) 6155890..6156186 + 297 WP_016984129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0G10_RS27305 (J0G10_27325) 6156241..6157053 - 813 WP_095048801.1 DUF2135 domain-containing protein -
J0G10_RS27310 (J0G10_27330) 6157057..6158676 - 1620 WP_095048802.1 DUF2300 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-62)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11651.55 Da        Isoelectric Point: 9.6908

>T196572 WP_016984129.1 NZ_CP071586:6155890-6156186 [Pseudomonas germanica]
MTYNLEFDRRALKEWNKLGDTVRHQFKKKLTEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDQEIVVFVIAIGK
REREAAYEVAQDRLSLLP

Download         Length: 297 bp

>T196572 NZ_CP095163:c2028460-2028359 [Edwardsiella anguillarum]
GCAAGGCATTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCATAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGCCAGGTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8865.24 Da        Isoelectric Point: 4.6017

>AT196572 WP_016984130.1 NZ_CP071586:6155661-6155900 [Pseudomonas germanica]
MASINIRIDDDLKQRSFAELEKLGVTPSELLRQTLQYVAERGKLPFKAALLSEEDEVLIAVVTERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT196572 NZ_CP095163:2028357-2028467 [Edwardsiella anguillarum]
ATAAAAAAAGACCTGGCACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTATGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAATGCCTTGCTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8GF58

Antitoxin

Source ID Structure
AlphaFold DB A0A4R7UU95

References