Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2687049..2687529 Replicon chromosome
Accession NZ_CP071586
Organism Pseudomonas germanica strain FIT28

Toxin (Protein)


Gene name relE Uniprot ID A0A7H8GNS0
Locus tag J0G10_RS12000 Protein ID WP_016983362.1
Coordinates 2687049..2687333 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V6Q6W5
Locus tag J0G10_RS12005 Protein ID WP_034152589.1
Coordinates 2687323..2687529 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G10_RS11965 (J0G10_11975) 2682365..2682838 + 474 WP_102902833.1 type II secretion system protein -
J0G10_RS11970 (J0G10_11980) 2682844..2683218 + 375 WP_095124774.1 type II secretion system protein -
J0G10_RS11975 (J0G10_11985) 2683193..2683732 + 540 WP_095124773.1 type II secretion system protein -
J0G10_RS11980 (J0G10_11990) 2683729..2684121 + 393 WP_095124772.1 curli production assembly/transport protein CsgE -
J0G10_RS11985 (J0G10_11995) 2684118..2684549 + 432 WP_095124771.1 curli assembly protein CsgF -
J0G10_RS11990 (J0G10_12000) 2684579..2685439 + 861 WP_220558534.1 CsgG/HfaB family protein -
J0G10_RS11995 (J0G10_12005) 2686504..2686875 + 372 WP_150707381.1 DUF6124 family protein -
J0G10_RS12000 (J0G10_12010) 2687049..2687333 - 285 WP_016983362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0G10_RS12005 (J0G10_12015) 2687323..2687529 - 207 WP_034152589.1 hypothetical protein Antitoxin
J0G10_RS12010 (J0G10_12020) 2687805..2689256 - 1452 WP_220558535.1 curlin -
J0G10_RS12015 (J0G10_12025) 2689284..2689748 - 465 WP_110721043.1 curlin -
J0G10_RS12020 (J0G10_12030) 2689821..2692049 - 2229 WP_220558536.1 Ig-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.69 Da        Isoelectric Point: 10.6629

>T196568 WP_016983362.1 NZ_CP071586:c2687333-2687049 [Pseudomonas germanica]
MQIKWRPKARVELSKILKYIGERNFVAATALHKSVVKTTSALCWHPHLYRKGRSPGTREIVVSPNYLVVYQVADQIEIVS
ILHARQEYPRRDPG

Download         Length: 285 bp

>T196568 NZ_CP095162:1494580-1495425 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATATTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCAAAAGAAGGTATTTCTTTCACAATTCAATCTATCACAGCAAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACCATTTTGTGCCAAATTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGCAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTACATATCGCGAAACAGAACTCGATTTTGCAAAGATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7672.54 Da        Isoelectric Point: 3.8068

>AT196568 WP_034152589.1 NZ_CP071586:c2687529-2687323 [Pseudomonas germanica]
MIDPSLIDPLCPVVSDLDPEEQAASYDRWFRAEVQASLDDPRPSIPHEQVMEEINALMESMRKSADAD

Download         Length: 207 bp

>AT196568 NZ_CP095162:1493993-1494583 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
GATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTGGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GTGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACTTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8GNS0

Antitoxin

Source ID Structure
AlphaFold DB A0A4V6Q6W5

References