Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 119766..120883 Replicon plasmid pLlyPCM2298_1
Accession NZ_CP071528
Organism Legionella lytica strain PCM 2298

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J2N86_RS14460 Protein ID WP_252582694.1
Coordinates 119766..120518 (-) Length 251 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J2N86_RS14465 Protein ID WP_252582695.1
Coordinates 120518..120883 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J2N86_RS14440 (J2N86_14470) 114972..116228 - 1257 WP_252582690.1 cyclic nucleotide-binding domain-containing protein -
J2N86_RS14445 (J2N86_14475) 116397..116876 + 480 WP_252582691.1 hypothetical protein -
J2N86_RS14450 (J2N86_14480) 116919..118355 - 1437 WP_252582693.1 UbiD family decarboxylase -
J2N86_RS14455 (J2N86_14485) 118700..119647 + 948 WP_252582746.1 sensor domain-containing diguanylate cyclase -
J2N86_RS14460 (J2N86_14490) 119766..120518 - 753 WP_252582694.1 RES family NAD+ phosphorylase Toxin
J2N86_RS14465 (J2N86_14495) 120518..120883 - 366 WP_252582695.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
J2N86_RS14470 (J2N86_14500) 120992..122416 - 1425 WP_252582697.1 phospholipase -
J2N86_RS14475 (J2N86_14505) 122774..122938 - 165 WP_252582698.1 hypothetical protein -
J2N86_RS14480 (J2N86_14510) 123012..123383 + 372 WP_252582700.1 hypothetical protein -
J2N86_RS14485 (J2N86_14515) 123531..123848 + 318 WP_252582702.1 hypothetical protein -
J2N86_RS14490 (J2N86_14520) 124767..125156 + 390 WP_252582703.1 DUF423 domain-containing protein -
J2N86_RS14495 (J2N86_14525) 125463..125810 - 348 WP_252582705.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..373394 373394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-207)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 28705.33 Da        Isoelectric Point: 4.9485

>T196564 WP_252582694.1 NZ_CP071528:c120518-119766 [Legionella lytica]
MVDIWLESDGKNHIKPLMAKIYRLVESQEQIATLGLVNNVYEQGVLEELLESTKNPLPSDTSTLHYLLTTPFRYPPLRYG
SRFGRTFEQGIFYGSLNVNTALSETAYYRFVYMLGPETPYEQPISNQYTSFTVKVRSSNSIFLDQDPFSQYEVILTSPTS
YIETQQLGSTMRESGIEIFQYISARDKEKGKNIALFTPKSFQSKTPAQMTTWLCQTSIDEVGFMAKEEQQRTSYSQKDFW
INNTFPSPAT

Download         Length: 753 bp

>T196564 NZ_CP095162:c888405-887638 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13546.72 Da        Isoelectric Point: 9.9707

>AT196564 WP_252582695.1 NZ_CP071528:c120883-120518 [Legionella lytica]
MNIESKPSESEVLAIALHNLKDILDISNNDLSEIIGVHRNTLSRSLSNKKIDVKSKEGECSLLLIRIYRSLFALNGGNVD
AMKHWLRTNNRHIQGIPLEAMKSVLGLSRVVNYLDAIRGKI

Download         Length: 366 bp

>AT196564 NZ_CP095162:c888881-888405 [Streptococcus suis]
ATGATTGGAGACAATATCAAGTCGCTACGCCGAACACATGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References