196562

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 25009..25534 Replicon plasmid p1_UPEC129
Accession NZ_CP071523
Organism Escherichia coli strain UPEC129

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag J3P56_RS24860 Protein ID WP_001159871.1
Coordinates 25229..25534 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag J3P56_RS24855 Protein ID WP_000813634.1
Coordinates 25009..25227 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P56_RS24850 22046..22687 - 642 WP_000990667.1 hypothetical protein -
J3P56_RS24855 25009..25227 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J3P56_RS24860 25229..25534 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
J3P56_RS24865 25535..26344 + 810 WP_000016979.1 site-specific integrase -
J3P56_RS24870 26482..26757 - 276 WP_000239529.1 hypothetical protein -
J3P56_RS24875 26751..27395 - 645 WP_000633911.1 AAA family ATPase -
J3P56_RS24880 27624..28595 + 972 WP_001103694.1 hypothetical protein -
J3P56_RS24885 28600..28992 + 393 WP_000340835.1 plasmid partitioning/stability family protein -
J3P56_RS24890 28997..30267 - 1271 Protein_32 translesion error-prone DNA polymerase V subunit UmuC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49605 49605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T196562 WP_001159871.1 NZ_CP071523:25229-25534 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T196562 NZ_CP095162:765731-767008 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AGCTAATAAAGACCGCCCTCAGTTACAAGCTATGCTTGCTTATATACGTGAAGGTGATATAGTGGTTGTGACAGAATTAG
AACGCCTGGGTAGGAATAACAAGGAGCTAACTGAGGTCATGAATGATATTCAAGCCAAGGGGGCAACCTTGGAAGTCTTA
AATCTTCCCACTCTTCGAGGGATTGAGGATGACAACCTGAGACGGCTCTTGAACAATCTTATCCTGGAACTCTACAAGTA
CCAGGCACAAGCTGAAAGGGAACGCATAAAGGAACGGCAACGCCAAGGGATAGCTATTGCCAAGACTCAAGGAAAGTACA
AAGGCAGAAAAGCCATTTTTTCAGAAGATGACAGCAGGCTTCTTCATGCCTTTGACCTTTACCTTGAAGGTCTATCAGAT
AAAGACGTTGCCAAGCTAACAGGTATCAACGAACGTACTTTTAGGCGGTATCGTGAAAAGCATAAGATAAAAAGATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT196562 WP_000813634.1 NZ_CP071523:25009-25227 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT196562 NZ_CP095162:765457-765729 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CQY2

References