Detailed information of TA system TA196557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4256920..4257740
• Replicon: chromosome
• Accession: NZ_CP071522
• Organism: Escherichia coli strain UPEC129

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: J3P56_RS20855
• Protein ID: WP_001054379.1
• Coordinates: 4256920..4257177 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: J3P56_RS20860
• Protein ID: WP_000123957.1
• Coordinates: 4257189..4257740 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3P56_RS20835	4252207..4253313	+	1107	WP_001332032.1	N-acetylneuraminate epimerase	-
J3P56_RS20840	4253377..4254357	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
J3P56_RS20845	4254940..4256166	-	1227	Protein_4077	helicase YjhR	-
J3P56_RS20850	4256244..4256543	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
J3P56_RS20855	4256920..4257177	+	258	WP_001054379.1	YjhX family toxin	Toxin
J3P56_RS20860	4257189..4257740	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
J3P56_RS20865	4257792..4258538	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
J3P56_RS20870	4258666..4258926	+	261	WP_000077645.1	hypothetical protein	-
J3P56_RS20875	4258964..4259080	+	117	Protein_4083	VOC family protein	-
J3P56_RS20880	4259325..4260446	+	1122	WP_000010833.1	M42 family metallopeptidase	-
J3P56_RS20885	4260443..4260721	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
J3P56_RS20890	4260733..4262046	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4249415..4265961	16546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T196557 WP_001054379.1 NZ_CP071522:4256920-4257177 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T196557 NZ_CP095161:c434015-433833 [Avibacterium paragallinarum]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGTAAAGTCGAAAATACAAAGCGAGGAAGCCATCGCAA
GGTAACGTTGAACGGACACCAAACTGTATTTCCCTACCACGGTAGTCAAGAAATCGGAACAGGGTTAGTTCACAAAATCA
AAAAAGACTTAAATTTAAAATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT196557 WP_000123957.1 NZ_CP071522:4257189-4257740 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT196557 NZ_CP095161:c433780-433361 [Avibacterium paragallinarum]
ATGTTACGTTATCCTGTTGAATTAAAAGCCGATGATAACGGCACGTTTCTTGTTACCTTTCCTGATATTCCCGAAGCGGC
AAGTGTAGGAGAAGACCTTGAAAGTGCCTTACTTGAAGCAGAGGAAGGATTAGAAACCGCACTGGAATTTTATTTTGATG
ATAAACGCCCAATCCCATTACCGAGTAAACCTCAAGAGGGGCAATATACTGTTCCGCTCTCTTTATTGCGCTCATTAAAA
GTGTTATTACTGAATGAAATGCTCGCTCAAGGTGTTCGCAAAGCAGAAATGGCTCGTCGCCTTGATGTACATATGCCACA
AATCGATCGCTTATTAGATTTTCGCTATCCTTCTAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAACTAGGGCGGGAAA
TTCATTTGGCGGTGAGTTAA

Structures

Toxin

• AlphaFold DB: B6I030