Detailed information of TA system TA196502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 795446..795957
• Replicon: chromosome
• Accession: NZ_CP071512
• Organism: Staphylococcus haemolyticus strain 1b

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: J2N83_RS03950
• Protein ID: WP_011275259.1
• Coordinates: 795751..795957 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: J2N83_RS03945
• Protein ID: WP_136719879.1
• Coordinates: 795446..795739 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J2N83_RS03920	790574..791365	+	792	WP_053025532.1	hydroxyethylthiazole kinase	-
J2N83_RS03925	791367..792005	+	639	WP_053025530.1	thiamine phosphate synthase	-
J2N83_RS03930	792094..792969	+	876	WP_037551964.1	membrane protein insertase YidC	-
J2N83_RS03935	793034..793675	-	642	WP_207323820.1	HD domain-containing protein	-
J2N83_RS03940	793775..795259	-	1485	WP_207323821.1	cardiolipin synthase	-
J2N83_RS03945	795446..795739	+	294	WP_136719879.1	copper-sensing transcriptional repressor CsoR	Antitoxin
J2N83_RS03950	795751..795957	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
J2N83_RS03955	796065..796202	+	138	WP_154392131.1	hypothetical protein	-
J2N83_RS03960	796251..797441	-	1191	WP_053025524.1	rod shape-determining protein RodA	-
J2N83_RS03965	797859..798929	+	1071	WP_053025522.1	D-alanine--D-alanine ligase	-
J2N83_RS03970	798945..800300	+	1356	WP_053025520.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T196502 WP_011275259.1 NZ_CP071512:795751-795957 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T196502 NZ_CP095145:326145-326513 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGATGCTAAACAAAATTGAATATGAAGGTGTGACAGATGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11235.91 Da
• Isoelectric Point: 7.3854

>AT196502 WP_136719879.1 NZ_CP071512:795446-795739 [Staphylococcus haemolyticus]
MNNHENAHHSKQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT196502 NZ_CP095145:325927-326148 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8