Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 957669..958440 Replicon chromosome
Accession NZ_CP071508
Organism Staphylococcus haemolyticus strain 7b

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag J2N84_RS04915 Protein ID WP_141738627.1
Coordinates 958291..958440 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag J2N84_RS04910 Protein ID WP_053025425.1
Coordinates 957669..958268 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J2N84_RS04890 953552..955006 + 1455 WP_053025432.1 ABC transporter substrate-binding protein/permease -
J2N84_RS04895 954999..955721 + 723 WP_037552178.1 amino acid ABC transporter ATP-binding protein -
J2N84_RS04900 955899..957026 + 1128 WP_053025430.1 tRNA epoxyqueuosine(34) reductase QueG -
J2N84_RS04905 957027..957497 + 471 WP_053025428.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
J2N84_RS04910 957669..958268 + 600 WP_053025425.1 glucosamine-6-phosphate isomerase Antitoxin
J2N84_RS04915 958291..958440 + 150 WP_141738627.1 hypothetical protein Toxin
J2N84_RS04920 958651..959046 + 396 WP_053025423.1 hypothetical protein -
J2N84_RS04925 959252..960637 + 1386 WP_053025421.1 class II fumarate hydratase -
J2N84_RS04930 960703..961527 - 825 WP_053025419.1 RluA family pseudouridine synthase -
J2N84_RS04935 961715..962824 + 1110 WP_207323845.1 GAF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5824.20 Da        Isoelectric Point: 3.9484

>T196501 WP_141738627.1 NZ_CP071508:958291-958440 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDRLNQSHE

Download         Length: 150 bp

>T196501 NZ_CP095143:c4067-3552 [Klebsiella pneumoniae]
ATGAAATTTTACACAATATCAAGCAGTTACATAAGATACCTGAAGGGCTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTATTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACGTCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCTGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGATAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCCTTACTTGATCTGGATAGCATGCCTAA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTGCCGTGTTAGAGGAAAAATATCAATATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22286.14 Da        Isoelectric Point: 4.7588

>AT196501 WP_053025425.1 NZ_CP071508:957669-958268 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PTSQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPADLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT196501 NZ_CP095143:c4204-4069 [Klebsiella pneumoniae]
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCT
TAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTTTTACGAGAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References