Detailed information of TA system TA196501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 957669..958440
• Replicon: chromosome
• Accession: NZ_CP071508
• Organism: Staphylococcus haemolyticus strain 7b

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: J2N84_RS04915
• Protein ID: WP_141738627.1
• Coordinates: 958291..958440 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: J2N84_RS04910
• Protein ID: WP_053025425.1
• Coordinates: 957669..958268 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J2N84_RS04890	953552..955006	+	1455	WP_053025432.1	ABC transporter substrate-binding protein/permease	-
J2N84_RS04895	954999..955721	+	723	WP_037552178.1	amino acid ABC transporter ATP-binding protein	-
J2N84_RS04900	955899..957026	+	1128	WP_053025430.1	tRNA epoxyqueuosine(34) reductase QueG	-
J2N84_RS04905	957027..957497	+	471	WP_053025428.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
J2N84_RS04910	957669..958268	+	600	WP_053025425.1	glucosamine-6-phosphate isomerase	Antitoxin
J2N84_RS04915	958291..958440	+	150	WP_141738627.1	hypothetical protein	Toxin
J2N84_RS04920	958651..959046	+	396	WP_053025423.1	hypothetical protein	-
J2N84_RS04925	959252..960637	+	1386	WP_053025421.1	class II fumarate hydratase	-
J2N84_RS04930	960703..961527	-	825	WP_053025419.1	RluA family pseudouridine synthase	-
J2N84_RS04935	961715..962824	+	1110	WP_207323845.1	GAF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5824.20 Da
• Isoelectric Point: 3.9484

>T196501 WP_141738627.1 NZ_CP071508:958291-958440 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDRLNQSHE

Nucleotide

• Length: 150 bp

>T196501 NZ_CP095143:c4067-3552 [Klebsiella pneumoniae]
ATGAAATTTTACACAATATCAAGCAGTTACATAAGATACCTGAAGGGCTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTATTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACGTCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCTGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGATAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCCTTACTTGATCTGGATAGCATGCCTAA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTGCCGTGTTAGAGGAAAAATATCAATATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22286.14 Da
• Isoelectric Point: 4.7588

>AT196501 WP_053025425.1 NZ_CP071508:957669-958268 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PTSQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPADLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT196501 NZ_CP095143:c4204-4069 [Klebsiella pneumoniae]
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCT
TAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTTTTACGAGAAAAA