Detailed information of TA system TA196496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 795433..795944
• Replicon: chromosome
• Accession: NZ_CP071505
• Organism: Staphylococcus haemolyticus strain 12b

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: J2N82_RS03940
• Protein ID: WP_011275259.1
• Coordinates: 795738..795944 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: J2N82_RS03935
• Protein ID: WP_136719879.1
• Coordinates: 795433..795726 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J2N82_RS03910	790561..791352	+	792	WP_053025532.1	hydroxyethylthiazole kinase	-
J2N82_RS03915	791354..791992	+	639	WP_053025530.1	thiamine phosphate synthase	-
J2N82_RS03920	792081..792956	+	876	WP_037551964.1	membrane protein insertase YidC	-
J2N82_RS03925	793021..793662	-	642	WP_207323820.1	HD domain-containing protein	-
J2N82_RS03930	793762..795246	-	1485	WP_207323821.1	cardiolipin synthase	-
J2N82_RS03935	795433..795726	+	294	WP_136719879.1	copper-sensing transcriptional repressor CsoR	Antitoxin
J2N82_RS03940	795738..795944	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
J2N82_RS03945	796052..796189	+	138	WP_154392131.1	hypothetical protein	-
J2N82_RS03950	796238..797428	-	1191	WP_053025524.1	rod shape-determining protein RodA	-
J2N82_RS03955	797846..798916	+	1071	WP_053025522.1	D-alanine--D-alanine ligase	-
J2N82_RS03960	798932..800287	+	1356	WP_053025520.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T196496 WP_011275259.1 NZ_CP071505:795738-795944 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T196496 NZ_CP095140:c4726335-4725802 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11235.91 Da
• Isoelectric Point: 7.3854

>AT196496 WP_136719879.1 NZ_CP071505:795433-795726 [Staphylococcus haemolyticus]
MNNHENAHHSKQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT196496 NZ_CP095140:c4726612-4726346 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8