Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 372648..374251 Replicon chromosome
Accession NZ_CP071502
Organism Shewanella sp. FJAT-52962

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JYB85_RS01545 Protein ID WP_207380759.1
Coordinates 372917..374251 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JYB85_RS01540 Protein ID WP_207380758.1
Coordinates 372648..372917 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYB85_RS01525 369930..370706 + 777 WP_207380756.1 hypothetical protein -
JYB85_RS01530 370681..371568 + 888 WP_207380757.1 transglutaminase domain-containing protein -
JYB85_RS01535 371750..372196 + 447 WP_207381945.1 IS200/IS605 family transposase -
JYB85_RS01540 372648..372917 + 270 WP_207380758.1 helix-turn-helix domain-containing protein Antitoxin
JYB85_RS01545 372917..374251 + 1335 WP_207380759.1 HipA domain-containing protein Toxin
JYB85_RS01550 374995..375831 + 837 WP_207380760.1 WYL domain-containing protein -
JYB85_RS01555 375944..376921 + 978 WP_207380761.1 type I-F CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 371750..372196 446
- inside Genomic island - - 364403..374251 9848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-55)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 49212.65 Da        Isoelectric Point: 6.5060

>T196492 WP_207380759.1 NZ_CP071502:372917-374251 [Shewanella sp. FJAT-52962]
MAVLDVYMNGYLIGEFTKTSTGAHYFSYHEDWLAVAGARPISLSMPLRRQAYKGDEVYNFFDNLLPDNPEVRNRIVARHQ
AVSSQPFDLLAKIGQDSVGALQLVPHGEVPVNVKQIESKALSEADLEKVLKGYLSGIPLGMLREQDEFRISIAGAQEKTA
LLNLNGQWRLPIHATPTTHIIKLPIGTIKGHSFNIDMSDSVENEFLCMKIAEAFGLTAAQCHIMKVGDIKALAVERFDRR
FAADGSWIMRLPQEDFCQVLNVPPANKYESDGGPGIQAIMDQLLGSTNPERDRHDFMKAQVLFWLLGAIDGHAKNFSIFI
DAGGSYRLAPLYDILSIYPALGGQGPNIRDVKLAMALKASKGKKAQLDAIFPRHFIQTAKAVGFDPDTMAGIMMEIADML
EPVIAKVRAELPTDFPEHIRESILNGLTERAKRLTAENIWQASR

Download         Length: 1335 bp

>T196492 NZ_CP095140:822332-822742 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10057.30 Da        Isoelectric Point: 8.5845

>AT196492 WP_207380758.1 NZ_CP071502:372648-372917 [Shewanella sp. FJAT-52962]
MKVTTSKQLSNYLKDARLAMKLSQSKVANKVGIRQDTVSSFEQNPDSTKLETLFKLLSSLNLELEVRPRASDADSAGTTH
DTQNWKEEW

Download         Length: 270 bp

>AT196492 NZ_CP095140:822085-822351 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References