Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1680735..1681348 | Replicon | chromosome |
| Accession | NZ_CP071491 | ||
| Organism | Glaesserella parasuis strain GHP1807 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | J1G54_RS08460 | Protein ID | WP_200859958.1 |
| Coordinates | 1680735..1680902 (+) | Length | 56 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A1T0AB61 |
| Locus tag | J1G54_RS08465 | Protein ID | WP_005714429.1 |
| Coordinates | 1680941..1681348 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J1G54_RS08415 | 1675862..1676407 | - | 546 | WP_021112377.1 | lysozyme | - |
| J1G54_RS08420 | 1676382..1676681 | - | 300 | WP_198525547.1 | hypothetical protein | - |
| J1G54_RS08425 | 1676795..1677358 | + | 564 | WP_021114960.1 | hypothetical protein | - |
| J1G54_RS08430 | 1677511..1677756 | - | 246 | WP_026916569.1 | hypothetical protein | - |
| J1G54_RS08435 | 1678233..1678820 | - | 588 | Protein_1643 | phage antirepressor N-terminal domain-containing protein | - |
| J1G54_RS08440 | 1679371..1679556 | + | 186 | WP_021109610.1 | hypothetical protein | - |
| J1G54_RS08445 | 1679565..1679942 | - | 378 | WP_207342672.1 | antitermination protein | - |
| J1G54_RS08450 | 1679939..1680343 | - | 405 | WP_160416363.1 | RusA family crossover junction endodeoxyribonuclease | - |
| J1G54_RS08455 | 1680340..1680630 | - | 291 | WP_005714426.1 | DUF1364 domain-containing protein | - |
| J1G54_RS08460 | 1680735..1680902 | + | 168 | WP_200859958.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J1G54_RS08465 | 1680941..1681348 | + | 408 | WP_005714429.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J1G54_RS08470 | 1681387..1681809 | - | 423 | WP_203399332.1 | recombination protein NinB | - |
| J1G54_RS08475 | 1682086..1682757 | - | 672 | WP_203399205.1 | holin | - |
| J1G54_RS08480 | 1682757..1683542 | - | 786 | WP_203399206.1 | replication protein | - |
| J1G54_RS08485 | 1683539..1684177 | - | 639 | WP_203399333.1 | phage regulatory protein/antirepressor Ant | - |
| J1G54_RS08490 | 1684273..1684518 | - | 246 | WP_160405314.1 | hypothetical protein | - |
| J1G54_RS08495 | 1684539..1684745 | - | 207 | WP_012621794.1 | helix-turn-helix transcriptional regulator | - |
| J1G54_RS08500 | 1684881..1685534 | + | 654 | WP_005714960.1 | LexA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1656799..1730082 | 73283 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 56 a.a. Molecular weight: 6272.42 Da Isoelectric Point: 11.0319
>T196491 WP_200859958.1 NZ_CP071491:1680735-1680902 [Glaesserella parasuis]
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
Download Length: 168 bp
>T196491 NZ_CP095140:354806-355153 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14890.91 Da Isoelectric Point: 4.6143
>AT196491 WP_005714429.1 NZ_CP071491:1680941-1681348 [Glaesserella parasuis]
MLYPLIFEQVSDGYVVAVPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
MLYPLIFEQVSDGYVVAVPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
Download Length: 408 bp
>AT196491 NZ_CP095140:355153-355452 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|