Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1658192..1658828 Replicon chromosome
Accession NZ_CP071491
Organism Glaesserella parasuis strain GHP1807

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYT4
Locus tag J1G54_RS08290 Protein ID WP_021113607.1
Coordinates 1658192..1658368 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143CEF9
Locus tag J1G54_RS08295 Protein ID WP_021113608.1
Coordinates 1658415..1658828 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G54_RS08275 1656120..1656500 - 381 WP_010786782.1 YacL family protein -
J1G54_RS08280 1656584..1656871 - 288 Protein_1612 excinuclease ABC subunit UvrA -
J1G54_RS08285 1656799..1657497 - 699 WP_157888994.1 hypothetical protein -
J1G54_RS08290 1658192..1658368 + 177 WP_021113607.1 type II toxin-antitoxin system HicA family toxin Toxin
J1G54_RS08295 1658415..1658828 + 414 WP_021113608.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1G54_RS08300 1658825..1659367 - 543 Protein_1616 phage minor tail protein L -
J1G54_RS08305 1659351..1662506 - 3156 WP_203399198.1 tape measure protein -
J1G54_RS08310 1662631..1663155 - 525 WP_062924269.1 Rha family transcriptional regulator -
J1G54_RS08315 1663290..1663550 - 261 WP_021118484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1656799..1730082 73283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6704.84 Da        Isoelectric Point: 10.8513

>T196490 WP_021113607.1 NZ_CP071491:1658192-1658368 [Glaesserella parasuis]
MKQSEFLRWLIAQGVVKEEGSKHIKLYYNGNQSTMPRQPSKEIKNGTMRAIKKQLGLN

Download         Length: 177 bp

>T196490 NZ_CP095140:328836-329204 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15572.78 Da        Isoelectric Point: 4.3878

>AT196490 WP_021113608.1 NZ_CP071491:1658415-1658828 [Glaesserella parasuis]
MLYPARFEFEDGSYNVSFRDIPEALTCGDNYEDALEMAKDALLTSMDFYFEDHRKVPLPSPPQEGEVLIELPTSIFAKVL
LLNEMVDQNISNVELAKRIAVKPQEVQRITNLGHSTKIDTIARAINALDKQFELRVV

Download         Length: 414 bp

>AT196490 NZ_CP095140:328618-328839 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYT4

Antitoxin

Source ID Structure
AlphaFold DB A0A143CEF9

References