Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 721238..721773 Replicon chromosome
Accession NZ_CP071491
Organism Glaesserella parasuis strain GHP1807

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag J1G54_RS03890 Protein ID WP_010785923.1
Coordinates 721489..721773 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag J1G54_RS03885 Protein ID WP_021118772.1
Coordinates 721238..721492 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G54_RS03865 716792..717334 + 543 WP_010785927.1 adenine phosphoribosyltransferase -
J1G54_RS03870 717424..719442 + 2019 WP_021118771.1 DNA polymerase III subunit gamma/tau -
J1G54_RS03875 719448..720344 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
J1G54_RS03880 720366..721121 + 756 WP_021112098.1 ABC transporter permease -
J1G54_RS03885 721238..721492 + 255 WP_021118772.1 hypothetical protein Antitoxin
J1G54_RS03890 721489..721773 + 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G54_RS03895 721983..723533 + 1551 WP_021116606.1 exodeoxyribonuclease I -
J1G54_RS03900 723616..724575 + 960 WP_203398968.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
J1G54_RS03905 724724..725545 + 822 WP_005712684.1 PHP domain-containing protein -
J1G54_RS03910 725652..726143 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T196486 WP_010785923.1 NZ_CP071491:721489-721773 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T196486 NZ_CP095137:c4216327-4215950 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT196486 WP_021118772.1 NZ_CP071491:721238-721492 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT196486 NZ_CP095137:c4216784-4216416 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References