Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 383900..384539 Replicon chromosome
Accession NZ_CP071491
Organism Glaesserella parasuis strain GHP1807

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J1G54_RS02120 Protein ID WP_207342802.1
Coordinates 384204..384539 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J1G54_RS02115 Protein ID WP_164681833.1
Coordinates 383900..384196 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G54_RS02090 378953..380140 + 1188 WP_015939681.1 elongation factor Tu -
J1G54_RS02095 380278..380868 - 591 WP_207342905.1 transposase -
J1G54_RS02100 381256..381585 + 330 Protein_402 transposase -
J1G54_RS02105 381613..382737 - 1125 Protein_403 IS3 family transposase -
J1G54_RS02110 382838..383827 - 990 WP_021110908.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
J1G54_RS02115 383900..384196 - 297 WP_164681833.1 putative addiction module antidote protein Antitoxin
J1G54_RS02120 384204..384539 - 336 WP_207342802.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G54_RS02125 384699..385103 + 405 WP_207342803.1 DNA polymerase III subunit psi -
J1G54_RS02130 385218..385529 + 312 WP_042906459.1 hypothetical protein -
J1G54_RS02135 385623..385907 + 285 WP_160442528.1 hypothetical protein -
J1G54_RS02140 385983..386465 + 483 WP_207342804.1 hypothetical protein -
J1G54_RS02145 386652..387394 + 743 Protein_411 transposase -
J1G54_RS02150 387584..387769 - 186 WP_005713975.1 zf-HC2 domain-containing protein -
J1G54_RS02155 387766..388338 - 573 WP_035522608.1 sigma-70 family RNA polymerase sigma factor -
J1G54_RS02160 388480..388809 + 330 WP_021113605.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-94)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12225.91 Da        Isoelectric Point: 9.5918

>T196483 WP_207342802.1 NZ_CP071491:c384539-384204 [Glaesserella parasuis]
MSGIINQIVITDNFSKWLDGLKNPIAKATVARRIKNTVKGNFDDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGSDKSTQQVDIEKAKALWAELKQTGGSNEY

Download         Length: 336 bp

>T196483 NZ_CP095137:c3806770-3805850 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10948.49 Da        Isoelectric Point: 4.8951

>AT196483 WP_164681833.1 NZ_CP071491:c384196-383900 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Download         Length: 297 bp

>AT196483 NZ_CP095137:c3807539-3806757 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References