Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1648543..1649171 Replicon chromosome
Accession NZ_CP071490
Organism Glaesserella parasuis strain GHP1808

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J1G53_RS08265 Protein ID WP_010786741.1
Coordinates 1648989..1649171 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J1G53_RS08260 Protein ID WP_010786740.1
Coordinates 1648543..1648956 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G53_RS08225 1643991..1644425 - 435 WP_075605972.1 hypothetical protein -
J1G53_RS08230 1644496..1645179 - 684 WP_005714533.1 helix-turn-helix transcriptional regulator -
J1G53_RS08235 1645310..1645510 + 201 WP_005714531.1 helix-turn-helix domain-containing protein -
J1G53_RS08240 1645790..1646485 + 696 WP_207342459.1 Rha family transcriptional regulator -
J1G53_RS08245 1646482..1647312 + 831 WP_207342423.1 DNA replication protein -
J1G53_RS08250 1647312..1647986 + 675 WP_207342422.1 holin -
J1G53_RS08255 1648081..1648509 + 429 WP_207342614.1 recombination protein NinB -
J1G53_RS08260 1648543..1648956 - 414 WP_010786740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1G53_RS08265 1648989..1649171 - 183 WP_010786741.1 type II toxin-antitoxin system HicA family toxin Toxin
J1G53_RS08270 1649272..1649448 + 177 WP_207342460.1 hypothetical protein -
J1G53_RS08275 1649420..1649989 + 570 WP_026916882.1 recombination protein NinG -
J1G53_RS08280 1649986..1650363 + 378 WP_075592771.1 antitermination protein -
J1G53_RS08285 1650385..1650822 - 438 WP_005714900.1 type II toxin-antitoxin system HicB family antitoxin -
J1G53_RS08290 1650852..1651037 - 186 WP_075592772.1 type II toxin-antitoxin system HicA family toxin -
J1G53_RS08295 1651261..1651698 - 438 WP_173655637.1 hypothetical protein -
J1G53_RS08300 1651705..1652324 - 620 Protein_1605 transposase -
J1G53_RS08305 1652795..1653217 - 423 WP_010786745.1 type II toxin-antitoxin system YafO family toxin -
J1G53_RS08310 1653210..1653752 - 543 WP_160413598.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1590810..1664815 74005
- flank IS/Tn - - 1651705..1652142 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6756.93 Da        Isoelectric Point: 10.7209

>T196480 WP_010786741.1 NZ_CP071490:c1649171-1648989 [Glaesserella parasuis]
VDSKTIIKMIEADGWKFHHATGSHHHFTHPIKKGIVTVIHPKKDLKKGTEHSILKQAGLK

Download         Length: 183 bp

>T196480 NZ_CP071490:c1649171-1648989 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGAAATTTCACCATGCAACAGGAAGTCACCACCACTT
CACTCACCCAATCAAAAAAGGCATTGTTACTGTCATTCATCCCAAAAAGGATTTAAAAAAAGGAACAGAACATTCAATAC
TAAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15280.41 Da        Isoelectric Point: 4.4693

>AT196480 WP_010786740.1 NZ_CP071490:c1648956-1648543 [Glaesserella parasuis]
MLYPIAIEPGDETHAFGVVVPDIPGCFSAGDTLEEAYSNAKEAILGHLELLVELGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT196480 NZ_CP071490:c1648956-1648543 [Glaesserella parasuis]
ATGTTATATCCAATTGCAATCGAACCAGGCGATGAAACCCACGCATTTGGCGTTGTTGTGCCTGATATTCCAGGCTGTTT
CTCTGCCGGCGATACGCTTGAAGAAGCCTACAGCAACGCAAAAGAAGCGATTCTTGGTCATCTTGAGTTATTAGTTGAAC
TTGGCGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTCTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References