Detailed information of TA system TA196478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1309099..1309638
• Replicon: chromosome
• Accession: NZ_CP071490
• Organism: Glaesserella parasuis strain GHP1808

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8F4J8
• Locus tag: J1G53_RS06285
• Protein ID: WP_010786322.1
• Coordinates: 1309099..1309368 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8F4J9
• Locus tag: J1G53_RS06290
• Protein ID: WP_005714576.1
• Coordinates: 1309372..1309638 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1G53_RS06265	1304144..1304665	-	522	WP_075592533.1	Rha family transcriptional regulator	-
J1G53_RS06270	1304743..1305075	-	333	WP_075592534.1	phage tail protein	-
J1G53_RS06275	1305120..1308686	-	3567	WP_207342419.1	tape measure protein	-
J1G53_RS06280	1308749..1309015	-	267	WP_075605747.1	hypothetical protein	-
J1G53_RS06285	1309099..1309368	-	270	WP_010786322.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J1G53_RS06290	1309372..1309638	-	267	WP_005714576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J1G53_RS06295	1309707..1309934	-	228	WP_005714573.1	DUF4035 domain-containing protein	-
J1G53_RS06300	1309979..1310380	-	402	WP_005714571.1	hypothetical protein	-
J1G53_RS06305	1310454..1311119	-	666	WP_160405387.1	hypothetical protein	-
J1G53_RS06310	1311122..1311541	-	420	WP_005714567.1	phage tail protein	-
J1G53_RS06315	1311541..1312074	-	534	WP_207342420.1	phage tail protein	-
J1G53_RS06320	1312078..1312383	-	306	WP_005714563.1	phage tail protein	-
J1G53_RS06325	1312376..1312702	-	327	WP_075605745.1	DUF2190 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1249433..1337499	88066

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-80)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10294.03 Da
• Isoelectric Point: 6.8591

>T196478 WP_010786322.1 NZ_CP071490:c1309368-1309099 [Glaesserella parasuis]
MLQLSPTNAYKRDFKKIASELMASAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Nucleotide

• Length: 270 bp

>T196478 NZ_CP095137:2235897-2235999 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9945.38 Da
• Isoelectric Point: 5.0366

>AT196478 WP_005714576.1 NZ_CP071490:c1309638-1309372 [Glaesserella parasuis]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Nucleotide

• Length: 267 bp

>AT196478 NZ_CP095137:c2236037-2235769 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: B8F4J8

Antitoxin

• AlphaFold DB: B8F4J9