Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 679637..680172 Replicon chromosome
Accession NZ_CP071490
Organism Glaesserella parasuis strain GHP1808

Toxin (Protein)


Gene name relE Uniprot ID A0A836YZW4
Locus tag J1G53_RS03285 Protein ID WP_016528228.1
Coordinates 679888..680172 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag J1G53_RS03280 Protein ID WP_010785924.1
Coordinates 679637..679891 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G53_RS03260 675193..675735 + 543 WP_075592519.1 adenine phosphoribosyltransferase -
J1G53_RS03265 675823..677841 + 2019 WP_075592518.1 DNA polymerase III subunit gamma/tau -
J1G53_RS03270 677847..678743 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
J1G53_RS03275 678765..679520 + 756 WP_075592517.1 ABC transporter permease -
J1G53_RS03280 679637..679891 + 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
J1G53_RS03285 679888..680172 + 285 WP_016528228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G53_RS03290 680381..681931 + 1551 WP_075592516.1 exodeoxyribonuclease I -
J1G53_RS03295 682014..682973 + 960 WP_075592515.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
J1G53_RS03300 683122..683943 + 822 WP_112063032.1 PHP domain-containing protein -
J1G53_RS03305 684049..684540 - 492 WP_160440681.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11276.27 Da        Isoelectric Point: 10.5362

>T196475 WP_016528228.1 NZ_CP071490:679888-680172 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
RERNDVYQKVQLRL

Download         Length: 285 bp

>T196475 NZ_CP095137:1971130-1971381 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT196475 WP_010785924.1 NZ_CP071490:679637-679891 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT196475 NZ_CP095137:1971378-1971632 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZW4

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References