Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1859410..1860049 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name relE Uniprot ID A0A8A2WDH5
Locus tag J1G50_RS09220 Protein ID WP_021110906.1
Coordinates 1859714..1860049 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J1G50_RS09215 Protein ID WP_164681833.1
Coordinates 1859410..1859706 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS09190 1854457..1855644 + 1188 WP_016527483.1 elongation factor Tu -
J1G50_RS09195 1856141..1856578 - 438 WP_164689363.1 IS1 family transposase -
J1G50_RS09200 1856759..1857088 + 330 Protein_1783 transposase -
J1G50_RS09205 1857116..1858247 - 1132 Protein_1784 IS3 family transposase -
J1G50_RS09210 1858348..1859337 - 990 WP_160405624.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
J1G50_RS09215 1859410..1859706 - 297 WP_164681833.1 putative addiction module antidote protein Antitoxin
J1G50_RS09220 1859714..1860049 - 336 WP_021110906.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G50_RS09225 1860208..1860612 + 405 WP_021110905.1 DNA polymerase III subunit psi -
J1G50_RS09230 1860727..1861038 + 312 WP_042906459.1 hypothetical protein -
J1G50_RS09235 1861132..1861416 + 285 WP_148122864.1 hypothetical protein -
J1G50_RS09240 1861492..1861962 + 471 WP_021110902.1 hypothetical protein -
J1G50_RS09245 1862161..1862901 + 741 Protein_1792 transposase -
J1G50_RS09250 1863094..1864062 - 969 Protein_1793 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1856759..1866951 10192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-93)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12209.91 Da        Isoelectric Point: 9.5918

>T196472 WP_021110906.1 NZ_CP071489:c1860049-1859714 [Glaesserella parasuis]
MSGIINQIIITDNFSKWLDGLKNPIAKATVARRIKNTVKGNFDDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTQQVDIEKAKALWAELKQTGGSNEY

Download         Length: 336 bp

>T196472 NZ_CP095137:689778-690092 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10948.49 Da        Isoelectric Point: 4.8951

>AT196472 WP_164681833.1 NZ_CP071489:c1859706-1859410 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Download         Length: 297 bp

>AT196472 NZ_CP095137:690089-690505 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References