Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1543254..1543789 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag J1G50_RS07605 Protein ID WP_010785923.1
Coordinates 1543254..1543538 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag J1G50_RS07610 Protein ID WP_021118772.1
Coordinates 1543535..1543789 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS07585 1538884..1539375 + 492 WP_005712683.1 acetolactate synthase small subunit -
J1G50_RS07590 1539482..1540303 - 822 WP_160404629.1 PHP domain-containing protein -
J1G50_RS07595 1540452..1541411 - 960 WP_160404628.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
J1G50_RS07600 1541494..1543044 - 1551 WP_010785922.1 exodeoxyribonuclease I -
J1G50_RS07605 1543254..1543538 - 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G50_RS07610 1543535..1543789 - 255 WP_021118772.1 hypothetical protein Antitoxin
J1G50_RS07615 1543906..1544661 - 756 WP_021112098.1 ABC transporter permease -
J1G50_RS07620 1544683..1545579 - 897 WP_005712691.1 ABC transporter ATP-binding protein -
J1G50_RS07625 1545585..1547603 - 2019 WP_021118771.1 DNA polymerase III subunit gamma/tau -
J1G50_RS07630 1547691..1548233 - 543 WP_010785927.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T196470 WP_010785923.1 NZ_CP071489:c1543538-1543254 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T196470 NZ_CP095137:338267-338794 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT196470 WP_021118772.1 NZ_CP071489:c1543789-1543535 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT196470 NZ_CP095137:337994-338260 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References